Hyperactivation of signal transducer and activator transcription 3 (STAT3) is strongly associated with cancer initiation, progression, metastasis, chemoresistance, immune evasion; thus, STAT3 has been intensely studied as a therapeutic target for treatment. Berberine (BBR), an active component extracted from Coptis chinensis , shown anti-tumor effects in multiple tumors. However, its underlying...

Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK cells, NKT cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining lymph nodes (TDLN...

Abstract Background Bacteria and respiratory viruses co-occur in the nasopharynx, their interactions may impact pathogenesis of invasive disease. Associations bacteria nasopharynx be affected by HIV. Methods We conducted a nested case-control study from larger cohort banked nasopharyngeal swabs families with without HIV West Bengal India, to look at association parents children when they are as...

brain injuries that caused by strokes (result of intra partum ischemia) are a frequent cause of prenatal mortality and morbidity with limited therapeutic options. transplanting human mesenchymal stem cells (hmscs) indicates improvement in hypoxic ischemic brain injury (hibd) by secretion growth factor stimulating repair processes (hmscs) known as multi potent cells which isolated from bone marr...

Introduction. Bladder cancer (BCa) is one the most common urinary system malignancies and approximately quarter of diagnosis invasive muscle-invasive BCa. Accumulating evidence revealed that keratin 17 (KRT17) closely related to prognosis progression various tumors including a recent study also implying potential role KRT17 in However, specific BCa remains be elucidated. Material methods. The e...

The study of pathogenic systems involved in multiple sclerosis (MS) is essential for the development new therapies. Objective : to determine contribution B-lymphocytes production IL-17 MS with an assessment ability B-cells induce differentiation Th17 and own by this pathology. Material methods . A total 81 subjects were examined, 68 whom patients diagnosed MS, 13 healthy individuals. concentrat...

The prototype discussed in this article retrieves Essential Terrestrial Variable (ETV) web services and uses data-model workflows to transform ETV data for hydrological models in a distributed computing environment. The ETV workflow is a service layer to 100's of terabytes of national datasets bundled for fast data access in support of watershed modeling using the United States Geological Surve...

Previous studies have shown that CD61 (integrin-β3) promotes the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into germ-like cells. However, the mechanism remains unclear. In this study, we showed that overexpression of CD61 in canine adipose-derived mesenchymal stem cells (cADMSCs) promotes their differentiation into primordial germ cell (PGC)-like cells. Quantitat...