OBJECTIVE Two similarly designed, phase-3 studies (VEGF Trap-Eye: Investigation of Efficacy and Safety in Wet AMD [VIEW 1, VIEW 2]) of neovascular age-related macular degeneration (AMD) compared monthly and every-2-month dosing of intravitreal aflibercept injection (VEGF Trap-Eye; Regeneron, Tarrytown, NY, and Bayer HealthCare, Berlin, Germany) with monthly ranibizumab. DESIGN Double-masked, ...

The surface ozone time series is analyzed for the seasonal and inter-annual variations and the trend in the following three categories (a) monthly mean (b) 8 hr monthly mean and (c) daily maximum monthly mean measured at 8 (urban/suburban) sites in Portugal for the period 2000–2010. The inter-annual variation of the monthly mean surface ozone time series showed an year to year variation with th...

BACKGROUND/AIMS The aim of this study was to assess the efficacy and safety of monthly oral 150 mg ibandronate in women with postmenopausal osteoporosis (PMO). METHODS A systematic review and meta-analysis were performed to determine treatment efficacy and safety outcomes between monthly oral 150 mg ibandronate and weekly 70 mg alendronate, daily 2.5 mg ibandronate, and a placebo. RESULTS E...