We present an automatic video processing system for tracking analysis in the Morris water escape testing videos. This system is able to extract automatically from such videos information (metadata) describing the spatiotemporal trajectories of animals in the maze and the timings of behavioral events such as stopping or crossing of a target area. The specific semantic metadata are produced by th...

The submerged platform or Morris water escape task is widely used to study genetic variation in spatial learning and memory, but interpretation is sometimes difficult because of wall hugging, jumping off the platform, floating or non-spatial swim strategies. We modified the task by introducing four wide arms into the circular tank and adding features that reduced, eliminated, or compensated for...

Background and Aim: Learning and memory defect occurs following chronic diabetes with uncontrolled blood glucose. Ginkgo leaf extract improves brain blood flow. Also it contains antioxidant components and has shown beneficial effects in neurological diseases. In this study we investigated the effects of Ginkgo leaf extract on spatial memory impairment and hippocampal neuronal loss caused by dia...

Data on the effects of serotonin reuptake inhibitors on learning and memory processes are not consistent. In the present study, the effects of citalopram, a very potent and completely selective inhibitor of the serotonin reuptake on spatial discrimination in the T-maze and Morris water maze, were assessed in mice and/or rats. Animals received different doses of citalopram (1, 2, 4, 8 or 16 mg/k...

This study is aimed at investigating the effects of methylphenidate about search strategy use on the spontaneously hypertensive rat, an animal model of attention-deficit/hyperactivity disorder in the Morris water maze. The methylphenidate group rats were given intraperitoneal injection of methylphenidate (10 mg/kg) dissolved in saline 30 min before daily training for 6 consecutive days. In the ...

The aim of this study was to observe the effects of jujube on learning and memory in ovariectomized rats. The effects of jujube on learning and memory in ovariectomized rats were observed using the Morris water maze method. The serum follicle-stimulating hormone (FSH), estrogen and luteinizing hormone (LH) levels, and the brain nitric oxide synthase (NOS) and acetylcholinesterase (AChE) levels ...

................................................................................................. 3 COGNITION AND SOCIAL BEHAVIOUR IN SCHIZOPHRENIA...............................3 TABLE OF CONTENTS............................................................................. 7 ABBREVIATIONS....................................................................................... 9 BACKGROUND..........

The objective of the current study was to determine whether prenatal iron deficiency induced during gestation in guinea pigs affected locomotor activity and learning and memory processes in the progeny. Dams were fed either iron-deficient anemic or iron-sufficient diets throughout gestation and lactation. After weaning, all pups were fed an iron-sufficient diet. On postnatal day 24 and 40, the ...

The misuse of anabolic androgenic steroids has in several reports been associated with effects resulting in altered behavior. This study used the Morris water maze task to investigate the effect of high doses of the anabolic androgenic steroid nandrolone on spatial learning and memory in male rats. During the experiment, we observed a significantly impaired Morris water maze performance in the ...

The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representing different animal strategies. However, these approaches typically consider t...