The purpose of this study was to evaluate the potential neurodevelopmental toxicity of perchlorate exposure during gestation and the first 10 days of lactation. Mated Sprague-Dawley rats (25/exposure group) were given continual access to 0, 0.1, 1.0, 3.0, or 10.0 mg/kg-day ammonium perchlorate (AP) in drinking water, starting gestation day 0 (mating) through lactation day 10 (DL 10). One pup/se...

Synaptic plasticity is known to be intrinsically linked to cytoskeletal remodelling. In a new study published in this issue of The EMBO Journal, Rust et al have therefore generated and analysed a forebrain-specific mouse knockout of the actin-severing factor n-cofilin. Intriguingly, these mice exhibit a particular form of learning impairment-intact working memory but impaired spatial reference ...