Objective: Silybum marianum has been used for centuries in herbal medicine for treatment of liver diseases. Currently, there is no data available on the possible effects of silymarin on fetal development. This study aimed to investigate the teratogenic effect of silymarin on BALB/c mice fetuses. Materials and Methods: A total of 40 pregnant mice were divided into 4 groups of 10 mice each. Three...

Although the biokinetics, metabolism, and chemical toxicity of methyl tert-butyl ether are well known, little attention was paid to the potential toxic effects of MTBE on reproduction and development in mammals. To evaluate the effects of MTBE on pregnant animals, two groups (control and test) of NMRI mice were chosen. In test group 500 and 1000 mg/Kg of it were administered intraperitonealy at...

This investigation was undertaken to assess the combined effects of protein restriction and ultrasonic energy exposure during pregnancy on the maternal and fetal mouse. Pregnant female mice were fed diets containing either 18% casein (control diet) or 6% casein (restricted protein diet) during gestation. All animals were subjected to the ultrasonic exposure procedure (actual: 2.5 W/cm2 spatial ...

We developed a mouse model to compare the virulence of Campylobacter fetus strains with (S-plus) and without (Sminus) surface array protein (S-protein) capsules. In adult HA/ICR mice pretreated with ferric chloride, the LDF0 for S-plus strain 84-32 was 43.3 times lower than its spontaneous S-minus mutant 84-54. Seven strains of inbred mice were no more susceptible than the outbred strain. In co...

Adult pregnant mice were given i.v. injections of (3H)3-methylcholanthrene (20 muCi in 1.1 mug/mouse) or (14C)3-methylcholanthrene (1.0 muCi in 48 mug/mouse). Ethanol extracts of their tissues were chromatographed on Sephadex LH-20. Three groups of 3-methylcholanthrene metabolites were obtained: one group as yet unidentified, one containing the hydrocarbon and hydroxylated derivatives, and a th...