AIMS MRP-1, LRP and TOPO-II are all associated with protection of the cells from the adverse effects of various chemotherapeutics. The aim of this study was to measure the expression of these proteins in Wilms' tumor (WT). MATERIALS AND METHODS TMA block was constructed from 14 samples of WT's and from xenografts derived from them. Sections of the TMA were used for immunostaining against MRP-...

Resistance to drugs included in the multidrug-resistance phenotype has been attributed to overexpression of either mdr1 or MRP genes and their products in numerous cell lines, while coexpression, to our knowledge, has not previously been reported in the same cells. Human small cell lung cancer H69/VP cells were developed by continuous incubation in increasing doses of VP-16. In reverse transcri...

Resistance to drugs included in the multidrug-resistance phenotype has been attributed to overexpression of either mdrl or MRP genes and their products in numerous cell lines, while coexpression, to our knowledge, has not previously been reported in the same cells. Human small cell lung cancer H69/VP cells were developed by continuous incubation in increas ing doses of VP-16. In reverse transcr...

Resistance to drugs included in the multidrug-resistance phenotype has been attributed to overexpression of either mdrl or MRP genes and their products in numerous cell lines, while coexpression, to our knowledge, has not previously been reported in the same cells. Human small cell lung cancer H69/VP cells were developed by continuous incubation in increas ing doses of VP-16. In reverse transcr...

Failure of chemotherapy associated with expression of the multidrug resistance protein p170 frequently occurs in retinoblastoma (RB). Despite using cyclosporine, which inhibits p170 and improves our chemotherapy results, rare failures occur. In nonmetastatic primarily enucleated RBs, we show expression of p170 in 3 of 18 samples and expression of multidrug resistance protein (MRP), the second p...

In this article, a conceptual model, called MRP IV, is proposed in order to serve as a reference to develop a new production technology that integrates material planning decisions, production resource capacities and supply chain transport for the purpose of avoiding the suboptimization of these plans which, today, are usually generated sequentially and independently. This article aim is twofold...

Intra-umbilical injection of oxytocin has been used to hasten placental separation in retained placenta. A randomised controlled trial was done on 35 consequent women who fulfilled the criteria for retained placenta at the Department of Obstetrics & Gynaecology Ipoh Hospital. Nineteen patients who were recruited into the study group received intraumbilical injection of 301U oxytocin in 27mls sa...

Material requirements planning (MRP) has been a very popular and widely used multi-level inventory control method since 1970s. Recent developments in computer and information technology accelerate and facilitate the calculations necessary for MRP, but MRP is simply a system to open and trace the production/purchasing orders under pre-determined lead-time and lot size constraints. It does not di...