Analysis of the mouse genome has revealed eight multidrug resistance-associated (Mrp) transporters, with mouse homologs for all human MRPs except MRP8. Whereas MRP expression in tissues of humans and rats has been examined, no characterization exists for mice. Furthermore, the ontogeny of mouse Mrps is unknown, and such knowledge may be helpful in understanding age-related pharmacokinetics. The...

All clinical isolates of Streptococcus pyogenes (group A streptococcus) share the ability to resist phagocytosis and grow in human blood. In many strains, this property is due to the expression of a single antiphagocytic M protein, while other strains express more than one M-like molecule, of which the role in phagocytosis resistance is unclear. In particular, all S. pyogenes strains of the OF+...

The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small cell lung cancer (TOP2A) and brain metastasis operatively. The expression of MRP and TOP2A were performed using immunohistochemistry (IHC) staining, and the results were analyzed in correlation with clinicopathological data. A total of ...

The application of reliable markers is of major importance for predicting the prognosis of and instituting the appropriate postsurgical treatment of patients with breast cancer. Previously we showed that motility-related protein-1 (MRP-1), which is identical to CD9, regulates cell motility, and that cultured tumor cells transfected with MRP-1/CD9 cDNA have low motility and low metastatic potent...

Streptococcus suis gây bệnh cảnh đa dạng trên người, trong đó chính là viêm màng não và sốc nhiễm khuẩn với tỷ lệ tử vong cao. Mức độ có liên quan đến phân bố tuýp huyết thanh các gen độc lực của vi khuẩn. Mục tiêu: Tìm hiểu sự một số kiểu S. người. Phương pháp: Tiến cứu, thu thập, tích liệu lâm sàng, tìm thanh, Suis ở thể bệnh. Kết quả: Bệnh gặp nhiều nam giới (91,3%), chủ yếu 2 (92,5%). Hầu h...

The MRP (multidrug resistance protein) gene, a member of the ubiq ultous superfamily of ATP-binding cassette transporters, is associated with the multidrug resistance of mammalian cells to natural product anticancer agents. We have previously shown that abrogation of MRP expression by gene targeting leads to hypersensitivity to several drugs. In two independently produced MB? double knockout cl...

RNase MRP is a eukaryotic endoribonuclease involved in nucleolar and mitochondrial RNA processing events. RNase MRP is a ribonucleoprotein particle, which is structurally related to RNase P, an endoribonuclease involved in pre-tRNA processing. Most of the protein components of RNase MRP have been reported to be associated with RNase P as well. In this study we determined the association of thes...

sequences probably mediate their effect by binding, in a sequence-specific manner, a protein which activates transcription. The recognition of elevated concentrations of heavy metals (for example, zinc) probably occurs by binding of the zinc ions to this hypothetical metal regulatory protein (MRP), such that normally only a low porportion of MRP has bound zinc. It is proposed that zinc (or othe...

Many companies have excel, it is economy and well perform to use in material requirement planning (MRP) on excel. For several products, it, however, is complex problem to link the relationship between the tables of products because the relationship depends on bill of material (BOM). This paper presents algorithm to create MRP on excel, and links relationship between tables. The study reveals MR...

We have generated rat and murine monoclonal antibodies against multidrug resistance-associated protein (MRP), a M,. 180,000-195,000 membrane glycoprotein involved in a non-P-glycoprotein multidrug re sistance of human tumor cells. The antibodies were raised against two different segments of MRP and found to be suitable for protein blot analyses, immunohistochemical and cytochemical studies, as ...