Abstract Objectives To investigate if the addition of cloxacillin to vancomycin enhances activity both monotherapies for treating MSSA and MRSA experimental endocarditis (EE) in rabbits. Methods Vancomycin plus was compared with respective daptomycin. In vitro time–kill studies were performed using standard (105 cfu) high (108 inocula five MRSA, one glycopeptide-intermediate (GISA) strains. One...

Cases of skin infections caused by Panton–Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA), particularly USA300 clone, have been increasing in Japan. We report that clinical findings 5 patients with PVL-positive MRSA and compared to those four PVL-negative MRSA. Severities were significantly higher than Average durations antimicrobial therapy for 3.4-fold l...

The polarizing debate about how to control antimicrobial-resistant organisms in hospitals continues to focus on methi-cillin-resistant Staphylococcus aureus (MRSA) and the use of active surveillance cultures. In the United States, MRSA infection causes an estimated 18,650 deaths annually among hospitalized patients [1] and likely cost billions of dollars [2]. The National Nosocomial Infections ...

Objective(s): The novel healing choices for handling of infections due to multidrug resistant Staphylococcus aureus are reguired. HAMLET has been reported to be able to sensitize bacterial pathogens to traditional antimicrobial agents. The aim was to assess wound healing activity of methicillin in presence of HAMLET in methicillin resistant S. aureus (MRSA) infected wounds. Materials and Method...

Before an efficient control strategy for livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) in pigs can be decided upon, it is necessary to obtain a better understanding of how LA-MRSA spreads and persists within a pig herd, once it is introduced. We here present a mechanistic stochastic discrete-event simulation model for spread of LA-MRSA within a farrow-to-finish sow ...

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) may cause prolonged outbreaks of infections in neonatal intensive care units (NICUs). While the specific factors favouring MRSA spread on neonatal wards are not well understood, colonized infants, their relatives, or health-care workers may all be sources for MRSA transmission. Whole-genome sequencing may provide a new tool for eluci...

BACKGROUND AND OBJECTIVE Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality in NICUs and PICUs. Our objective was to assess the burden of MRSA colonization on admission, study the time trends, and examine the significance of MRSA colonization in this population. METHODS PubMed and Embase databases were consulted. Studies that reported prevalen...

BACKGROUND Selective chromogenic media allowing one-step meticillin-resistant Staphylococcus aureus (MRSA) isolation and identification are widely used. However, the changing epidemiology of MRSA means that the suitability of these chromogenic media requires investigation. AIM To evaluate the following chromogenic media - Colorex MRSA, MRSA Select II, ChromID MRSA, and MRSA Brilliance 2 - for...