Proinflammatory mononuclear phagocytes (MPs) play a crucial role in the progression of multiple sclerosis (MS) and other neurodegenerative diseases. Despite advances in neuroimaging, there are currently limited available methods enabling noninvasive detection of MPs in vivo. Interestingly, upon activation and subsequent differentiation toward a proinflammatory phenotype MPs undergo metabolic re...

The prognostic ability of global white matter and gray metabolite ratios following pediatric traumatic brain injury (TBI) their relationship to 12-month neuropsychological assessments intelligence quotient (IQ), attention, memory is presented. Three-dimensional proton magnetic resonance spectroscopic imaging (MRSI) in subjects with complicated mild (cMild), moderate, severe TBI was acquired acu...

Introduction HR-MAS metabolic profiles in biopsies has been useful for classifying and subtyping brain tumours [1,2]. However, HR-MAS can exclusively provide the average metabolic profile of the biopsy studied for very heterogeneous lesions as brain tumours. Metabolic spatial distribution by in vivo MRS imaging (MRSI) has been proven very helpful for improving the diagnosis, prognosis and treat...

A new method is proposed for spectral quantitation of MRSI data. The method has two main features: 1) incorporation of prior spectral knowledge in the form of basis functions obtained by quantum simulation, and 2) incorporation of prior spatial knowledge by penalizing smoothness within each type of tissue. An efficient algorithm is also proposed to solve the underlying optimization problem, and...

Introduction Therapeutic brain hypothermia is used with increasing frequency as a tool to mitigate neurologic injury [1]. It has been shown that moderate cooling of the brain after hypoxia-ischemia can reduce damage and improve functional outcome [2, 3]. Recently a new method for selective brain cooling was described and prototype device was tested on the pigs [4, 5]. Brain temperature decreasi...

Abstract Introduction A new generation of MR spectroscopic imaging (MRSI) methods using 7T scanners have demonstrated the capability to resolve more neuro- and oncometabolites at higher resolutions than clinical routine MRSI. In a cohort glioma patients, we explored automated preoperative noninvasive classification IDH-mutation status tumor grade based on Methods This retrospective study includ...

International Journal of Imaging Systems and TechnologyVolume 33, Issue 2 p. 770-770 CORRIGENDUMFree Access Correction to ‘ORYX-MRSI: A fully-automated open-source software for proton magnetic resonance spectroscopic imaging data analysis’ This article corrects the following: ORYX-MRSI: analysis Sevim Cengiz, Muhammed Yildirim, Abdullah Bas, Esin Ozturk-Isik, Volume 32Issue 4International Techn...

We present the magnetic resonance spectroscopy imaging (MRSI) analysis functionality of DIROlab, an integrated software platform for cancer diagnosis and therapy planning. Completely automated estimation of cancer probability from the spectral signature is achieved by state-of-theart statistical classification techniques; furthermore an easyto-use interface for spectrum labeling, classifier ret...

As prostate cancer is a biologically heterogeneous disease for which a variety of treatment options are available, the major objective of prostate cancer imaging is to achieve more precise disease characterization. In clinical practice, magnetic resonance imaging (MRI) is one of the imaging tools for the evaluation of prostate cancer, the fusion of MRI or dynamic contrast-enhanced MRI (DCE-MRI)...