Magnetic Resonance Spectroscopic Imaging (MRSI) measures relative concentrations of metabolites in vivo and can thus be used for the diagnosis of certain tumors. We introduce the program CLARET that makes MRSI accessible for clinical routine use. Instead of embarking on an error-prone quantification of metabolites that requires manual checking of the results in many voxels, the program uses pat...

Introduction Magnetic Resonance Spectroscopy of the brain reveals a wealth of metabolic information, not only from a single region of interest (single voxel MRS), but spatially mapped over potentially the entire brain as well (MRSI). Particularly for relatively highly concentrated compounds in the brain with weakly or non-coupled spin systems with relatively long T2 relaxation properties, like ...

OBJECTIVES To study the MRI findings of the pancreatic duct in patients with acute pancreatitis. MATERIALS AND METHODS A total of 239 patients with acute pancreatitis and 125 controls were analyzed in this study. The severity of acute pancreatitis was graded using the MR severity index (MRSI) and the Acute Physiology And Chronic Healthy Evaluation II(APACHE II) scoring systems. The number of ...

Experimental work in animal models of generalized epilepsy and clinical data in humans with idiopathic generalized epilepsy (IGE) indicate that the thalamo-cortical circuitry is involved in the generation of epileptic activity. The purpose of this study was to evaluate in vivo the chemical and structural integrity of the thalamus in patients with IGE. Thalamic proton magnetic resonance spectros...

BACKGROUND AND PURPOSE Childhood white matter disorders often show similar MR imaging signal-intensity changes, despite different underlying pathophysiologies. The purpose of this study was to determine if proton MR spectroscopic imaging ((1)H-MRSI) may help identify tissue pathophysiology in patients with leukoencephalopathies. MATERIALS AND METHODS Seventy patients (mean age, 6; range, 0.66...

background epilepsy, a well-known mostly idiopathic neurologic disorder, has to be correctly diagnosed and properly treated. up to now, several diagnostic approaches have been processed to determine the epileptic focus. objectives the aim of this study was to discover whether proton-mr-spectroscopic imaging (mrsi) aids in the diagnosis of temporal lobe epilepsy in conjunction with classical ele...

An accurate characterization of glioma heterogeneity is essential when determining tumor grade and the most appropriate therapy target. Non-invasive imaging modalities such as MR perfusion imaging (PWI) and 2D proton MR spectroscopic imaging (MRSI) can provide functional and metabolic information about the tumor to assist in this task. Using a voxel-wise correlation we aimed at investigating wh...

Diffusion tensor imaging (DTI) and MR spectroscopic imaging (MRSI) provide greater sensitivity than conventional MRI to detect diffuse alterations in normal appearing white matter (NAWM) of Multiple Sclerosis (MS) patients with different clinical forms. Therefore, the goal of this study is to combine DTI and MRSI measurements to analyze the relation between diffusion and metabolic markers, T2-w...

BACKGROUND AND PURPOSE The underlying changes in the neuronal connectivity adjacent to brain tumors cannot always be depicted by conventional MR imaging. The hypothesis of this study was that preoperative sensorimotor deficits are associated with impairment in pyramidal fiber bundles. Hence, we investigated the potential of combined quantitative diffusion tensor (DT) fiber tracking and MR spect...

Introduction Magnetic resonance spectroscopic imaging (MRSI) enables the acquisition of quantitative metabolite distribution maps with internal water referencing (IWR) [1] being the current method of choice for signal normalization and determination of mM concentrations. IWR accounts for B1 variations across the field of view but imposes problems when assessing diseases that lead to alteration ...