PURPOSE To minimize line shape distortions and spectral leakage artifacts in MR spectroscopic imaging (MRSI). METHODS A spatially and spectrally regularized non-Cartesian MRSI algorithm that uses the line shape distortion priors, estimated from water reference data, to deconvolve the spectra is introduced. Sparse spectral regularization is used to minimize noise amplification associated with ...

Magnetic resonance spectroscopic imaging (MRSI) detects alterations in major prostate metabolites, such as citrate (Cit), creatine (Cr), and choline (Ch). We evaluated the sensitivity and accuracy of three-dimensional MRSI of prostate using an endorectal compared to an external phased array "receive" coil on a 3T MRI scanner. Eighteen patients with prostate cancer (PCa) who underwent endorectal...

While magnetic resonance imaging (MRI) derives its signal from protons in water, additional biochemical compounds are detectable in vivo within the proton spectrum. The detection and mapping of these much weaker signals is known as magnetic resonance spectroscopy or spectroscopic imaging. Among the complicating factors for this modality applied to human clinical imaging are limited chemical-shi...

Preliminary findings in 10 MS patients suggest that axonal integrity (as reflected in H-MRSI NA/Cr values) within normalappearing white matter (NAWM) is strongly – but not completely – related (r2=0.53) to the structural integrity of NAWM [as reflected in diffusion-tensor-imaging fractional anisotropy (FA)]. The relationship between NAWM-NA/Cr and both (i) the amount of cerebro-functional compe...

BACKGROUND AND PURPOSE Noninvasive diagnosis of brain lesions is important for the correct choice of treatment. Our aims were to investigate whether 1) proton MR spectroscopic imaging ((1)H-MRSI) can aid in differentiating between tumors and nonneoplastic brain lesions, and 2) perfusion MR imaging can improve the classification. MATERIALS AND METHODS We retrospectively examined 69 adults with...

Water-suppressed MRS acquisition techniques have been the standard MRS approach used in research and for clinical scanning to date. The acquisition of a non-water-suppressed MRS spectrum is used for artefact correction, reconstruction of phased-array coil data and metabolite quantification. Here, a two-scan metabolite-cycling magnetic resonance spectroscopic imaging (MRSI) scheme that does not ...

INTRODUCTION: H magnetic resonance spectroscopic imaging (MRSI) can be used as a diagnostic tool to distinguish abnormal from normal tissue by obtaining metabolic information which can be used as biomarkers. MRSI can be improved by going to higher field strengths like 7 Tesla which offer increased spectral resolution and SNR. However, at these field strengths the non uniformity of the B1 field ...

Parallel imaging reconstruction has been successfully applied to magnetic resonance spectroscopic imaging (MRSI) to reduce scan times. For undersampled k-space data on a Cartesian grid, the reconstruction can be achieved in image domain using a sensitivity encoding (SENSE) algorithm for each spectral data point. Alternative methods for reconstruction with undersampled Cartesian k-space data are...

PURPOSE To develop a (1)H magnetic resonance spectroscopic imaging (MRSI) sequence that can be used to image infants/children at 3T and by combining it with diffusion tensor imaging (DTI) tractography, extract relevant metabolic information corresponding to the corticospinal tract (CST). MATERIALS AND METHODS A fast 3D MRSI sequence was developed for pediatric neuroimaging at 3T using spiral ...

MRSI in the brain at ≥7 T is a technique of great promise, but has been limited mainly by low B0/B1+-homogeneity, specific absorption rate restrictions, long measurement times, and low spatial resolution. To overcome these limitations, we propose an ultra-high resolution (UHR) MRSI sequence that provides a 128×128 matrix with a nominal voxel volume of 1.7×1.7×8mm3 in a comparatively short measu...