BACKGROUND Human induced pluripotent stem cells (iPSCs) possess remarkable self-renewal capacity and the potential to differentiate into novel cell types, such as mesenchymal stem cells (MSCs). iPSC-MSCs have been shown to enhance tissue regeneration and attenuate tissue ischaemia; however, their contribution to the immune regulation of Th2-skewed allergic rhinitis (AR) and asthma remains uncle...

Accumulating evidence suggests that mesenchymal stem cells (MSCs) are recruited to the tumor microenvironment; however, controversy exists regarding their role in solid tumors. In this study, we identified and confirmed the presence of carcinoma-associated MSCs (CA-MSCs) in the majority of human ovarian tumor samples that we analyzed. These CA-MSCs had a normal morphologic appearance, a normal ...

Mesenchymal stem cells (MSCs) are attractive agents for cellular therapy in rheumatoid arthritis (RA). The receptor for advanced glycation end products (RAGE) serves as a pattern recognition receptor for endogenous inflammatory ligands. Soluble RAGE (sRAGE) is a truncated form of RAGE that functions as a decoy and acts as an anti-inflammatory molecule. The aim of this study was to determine whe...

AIMS Mesenchymal stem cells (MSCs) can ameliorate myocardial infarction (MI) injury. However, older-donor MSCs seem less efficacious than those from younger donors, and the contributing underlying mechanisms remain unknown. Here, we determine how age-related expression of pigment epithelium-derived factor (PEDF) affects MSC therapeutic efficacy for MI. METHODS AND RESULTS Reverse transcriptas...

The cellular and molecular mechanisms responsible for pregnancy-related disorders remain unclear. We investigated the feasibility of using placenta-derived mesenchymal stem cells (MSCs) as a tool to study such pregnancy-related disorders. We isolated and expanded adequate numbers of cells with characteristic features of MSCs from the chorionic plate (CP-MSCs), chorionic villi (CV-MSCs), and dec...

Background: For years, scientists have been striving to identify compounds improve the characteristics and functions of cells for therapeutic applications. Objectives: This study aimed evaluate effect aqueous decoction internal septum walnut kernel (DISWK) on survival, total antioxidant capacity (TAC), cell cycle rat bone marrow-derived mesenchymal stem (rBM-MSCs). We also evaluated expression ...

Disorders of the esophagus could include various conditions such as inflammation, stricture or esophageal-phase dysphagia. Management these disorders is rapidly developing, which includes conservative, surgical and modern techniques use stem cells. Stem cells are characterized have not differentiated, able to multiply differentiate into multiple organ cells, has ability self-renewal vital in di...

Message Sequence Charts (MSCs) are a graphical and textual language for the speciication of message passing systems, in particular telecommunication systems. MSCs are standardised by the Internal Telecommunication Union in standard Z.120. Included in the standard is a formal semantics for MSCs by means of a process algebra. This semantics covers the complete language of single MSCs but lacks an...

The mesenchymal stem cells (MSCs), which are derived from the mesoderm, are considered as a readily available source for tissue engineering. They have multipotent differentiation capacity and can be differentiated into various cell types. Many studies have demonstrated that the MSCs identified from amniotic membrane (AM-MSCs) and amniotic fluid (AF-MSCs) are shows advantages for many reasons, i...