BACKGROUND This study compared the pharmacodynamics of ceftobiprole and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-intermediate S. aureus (VISA) and vancomycin-resistant S. aureus (VRSA) using an in vitro model. METHODS Two methicillin-susceptible S. aureus (MSSA), two community-associated (CA)-MRSA, one healthcare-associated (HA)-MRSA, three VISA and tw...

BACKGROUND Inhibition and eradication of Staphylococcus aureus biofilms with conventional antibiotic is difficult, and the treatment is further complicated by the rise of antibiotic resistance among staphylococci. Consequently, there is a need for novel antimicrobials that can treat biofilm-related infections and decrease antibiotics burden. Natural compounds such as eugenol with anti-microbial...

BACKGROUND New Zealand has a higher incidence of Staphylococcus aureus disease than other developed countries, with significant sociodemographic variation in incidence rates. In contrast to North America, the majority of disease is due to methicillin-susceptible S. aureus (MSSA), although relatively little is known about the comparative demographics of MSSA and methicillin-resistant S. aureus (...

Controversy continues regarding whether the presence of meticillin resistance increases mortality risk in Staphylococcus aureus infections. In this study, we assessed the role of meticillin resistance in survival of patients with S. aureus infection included in the EPIC II point-prevalence study of infection in critically ill patients performed on 8 May 2007. Demographic, physiological, bacteri...

OBJECTIVE To analyze multilocus sequence typing (MLST) of methicillin-resistant Staphylococcus aureus (MRSA) strains in 2000 and 2005, and get a primary knowledge of MLST Characterization of MRSA. METHODS Sequence analysis was conducted on seven allelic genes of 29 methicillin-resistant Staphylococcus aureus strains and 2 methicillin-sensitive Staphylococcus aureus (MSSA) strains and the alle...

The attenuation of coherent and random noise still poses technical challenges in seismic data processing, especially in onshore environments. Multichannel Singular Spectrum Analysis (MSSA) is an existing and effective technique for random-noise reduction. By incorporating a randomizing operator into MSSA, this modification creates a new and powerful filtering method that can attenuate both cohe...

Background: Methicillin Resistant Staphylococcus aureus (MRSA) is a variant of Staphylococcus aureus which is resistant to all ß-lactams. Infections due to (MRSA) strains have been detected worldwide and it makes the treatment of common infections much more difficult. Objectives: This study was carried out to determine and compare the Antibiotic susceptibility patterns in Methicillin Resistant ...

Adult community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and methicillin-susceptible S. aureus (CA-MSSA) skin and soft tissue infection (SSTI) in China is not well described. A prospective cohort of adults with SSTI was established between January 2009 and August 2010 at 4 hospitals in Beijing. Susceptibility testing and molecular typing, including multilocus sequence ty...

The study objective was to screen both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) isolates from blood cultures for reduced susceptibility to vancomycin and teicoplanin. A total of 72 MRSA and 143 MSSA isolates were screened on brain-heart infusion agar containing either 4 mg/L vancomycin or 8 mg/L teicoplanin, using an inoculum of approximately...

Methods. This was a single-center retrospective study of patients with MSSA BSIs from April 2008-December 2013. Inclusion criteria were: receipt of ≥48 hours of empiric therapy; ≥1 positive blood culture with MSSA; first positive culture drawn within 24 hours of starting empiric antibiotics. Exclusion criteria consisted of: use of antiMRSA therapy for concomitant infection; polymicrobial BSI; u...