Irvingia malayana has been utilized for traditional medicine in West Kalimantan, Indonesia.The aim of this research is to detect cytotoxic activity of extract of Irvingia malayana. The extraction with methanol and partition by variated eluen polarity. This extraction produced methanol extract, n-hexane fraction, methylene chloride fraction, ethylacetate fraction and methanol fraction. Cytotoxic...

AIM We aimed to evaluate changes in insulin and glucagon secretion, as well as glucose levels, with a meal tolerance test (MTT) before and after 6 months of treatment with vildagliptin in a clinical setting. MATERIALS AND METHODS Participants were 15 patients with uncontrolled type 2 diabetes mellitus (glycated hemoglobin [HbA1c] over 6.9% for more than 3 months). MTTs were conducted before a...

Hydroxyapatite-tricalcium phosphate (HA-TCP) scaffold is a three-dimensional structure used to support bone regeneration. Ideally, the should be biocompatible, biodegradable, and non-toxic. The tissue engineering technique uses combined stem cell repair defect. To prove non-toxic properties of scaffold, cytotoxicity test needed for human umbilical cord mesenchymal (HUCMSCs). In this study, 27 s...

BACKGROUND Pixel-based multimodality tissue tracking (MTT) is a new noninvasive method for the quantification of cardiac deformation from cine image of MRI. The aim of this study is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients. METHODS In 45 subjects (30 PH patients and 15 norm...

Souhrn: Bylo zpracováno 34 břišních a 24 hrudních výpotků pacientů s nádorovým onemocněním. U jedné čtvrtiny z těchto výpotků byla cytologicky potvrzena přítomnost maligních buněk. Byla vypracována metoda k jejich izolaci od příměsných benigních elemen­ tů. U 11 břišních a 6 hrudních výpotků umožnilo izolované množství nádorových buněk provedení MTT testu chemorezistence vůči cytostatikům. Větš...

BACKGROUND The tetrazolium dye (MTT) assay is useful for predicting chemosensitivity. MATERIALS AND METHODS Using the MTT assay, an in vitro chemosensitivity test was designed for nedaplatin (cis-diammine glycolato platinum; 254-S) and the results were compared with the sensitivity to cisplatin in 137 resected gynecological carcinomas. RESULTS The mean tumor inhibition rate [I.R.; %] for ne...