نتایج جستجو برای: mucoadhesive discs
تعداد نتایج: 15985 فیلتر نتایج به سال:
BACKGROUND AND OBJECTIVES Rheological evaluation of thermoreversible mucoadhesive nasal gel of zolmitriptan is done to determine the steady shear behaviour and gelation temperature. The thermoreversible mucoadhesive polymers are sucessesfully used to increase the contact time of the therapeutic compound in the nasal cavity as well as they cause enhancement in permeation of drug through the nasa...
PURPOSE To test the hypothesis that mucoadhesive microdiscs formulated in a rapidly dissolving tablet can increase preocular residence time. METHODS Microparticles smaller than 10 mum in diameter were fabricated by emulsification with poly(lactic-co-glycolic acid) as a core material and, in some cases, poly(ethylene glycol) as a mucoadhesion promoter. To examine the effect of particle geometr...
objective(s): drug delivery via mucosal routes has been confirmed to be effective in inducing strong immune responses. liposomes could enhance immune responses and mucoadhesive potentials, make them useful mucosal drug delivery systems. coating of liposomes by mucoadhesive polymers succeeded in enhancing immune responses. our studies aim at preparation and characterization of trimethylchitosan-...
the purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934p as mucoadhesive polymer and ethyl cellulose as carrier ...
Almost 40% of active Pharmaceutical ingredients have low oral bioavailability, high hepatic first-pass metabolism and also less efficient in crossing the blood brain barrier for brain targeting through oral delivery. To overcome this problem the various system such as: nasal spray, gels, emulsions, droplets, suspensions, powders and thermoreversible mucoadhesive gels etc have been studied for n...
The study is related to the formulation and evaluation of mucoadhesive buccal tablets Anastrozole enhance its bioavailability by avoiding 1st pass effect. succeeded in developing containing two layers (mucoadhesive backing layer) a design that permits unidirectional release drug. Tablets were prepared double direct compression method using (carbopol 934) as primary polymer, Sod.alginate, Na CMC...
The purpose of this research was to formulate and systemically evaluate in-vitro and in-vivo performances of mucoadhesive propranolol hydrochloride microspheres for its potential use in the treatment of hypertension, myocardial infraction and cardiac arrhythmias. Propranolol hydrochloride mucoadhesive microspheres, containing carbopol-934P as mucoadhesive polymer and ethyl cellulose as carrier ...
OBJECTIVE Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. MATERIALS AND METHODS Liposomes containing model drug atenolol were prepared by the modified eth...
Oral drug administration has been the predominant route for drug delivery due to the ease of administration, patient convenience and flexibility in formulations. Mucoadhesive tablets of Cephalexin monohydrate were prepared with an objective to increase the bioavailability by minimizing the first pass metabolism and also to reduce the frequency of administration. Carbopol 934p as a primary polym...
In this work, the dissolution-absorption studies were conducted on marketed tablets of acyclovir (ACIVIR-200mg) and the mucoadhesive tablets of acyclovir using varying concentration of sodium lauryl sulfate as a permeation enhancer. The purpose of this study was to improve the absorption of acyclovir using sodium lauryl sulfate as permeation enhancer. The everted and perfused intestine model wa...
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