To develop more potent and convenient mucosal vaccines, we investigated the effect of an in situ-gelling mucoadhesive vaginal vaccine delivery system and a genetic chemokine adjuvant on the local and systemic immune responses. The in situ-gelling mucoadhesive delivery system of hepatitis B surface antigen (HBsAg), composed of poloxamers and polycarbophil, showed the prolonged retention at the v...

A new, novel promising technology for obtaining controlled release and enhancing the bioavailability is a combination of mucoadhesion principle and microencapsulation to result in mucoadhesive microcapsules. Mucoadhesive microcapsules consist of either entirely of a mucoadhesive polymer or having an outer coating enclosing the drug particles. They facilitate an intimate and prolonged contact wi...

The purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. A 32 full factorial design was employed to study the effect of independent variables like Carbopol-934P and hydroxypropyl methylcellulose K100M, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...

      Mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. Several synthetic polymers are in use for this purpose. Since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controll...

BACKGROUND Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications and drug delivery. However, few reports have focused on the keratin-based mucoadhesive drug delivery system and their mechanisms of mucoadhesion. Thus, the mucoadhesion controll...

The aim of this study was to investigate the rheological behavior and mucoadhesive nature of saliva substitutes, by incorporating various mucoadhesive polymers into an artificial saliva pump spray formulation. For this purpose various mucoadhesive polymers including cellulosic polymers in the range of 0.1-1.0% and Carbomers such as C974p, C971, C934p and C971 in the range of 0.01-0.1% were adde...

The aim of this study was to investigate the rheological behavior and mucoadhesive nature of saliva substitutes, by incorporating various mucoadhesive polymers into an artificial saliva pump spray formulation. For this purpose various mucoadhesive polymers including cellulosic polymers in the range of 0.1-1.0% and Carbomers such as C974p, C971, C934p and C971 in the range of 0.01-0.1% were adde...

buccoadhesive drug delivery systems have distinct advantages in comparison with oral administration. plant exudates like gum or mucilage are being studied for their use as pharmaceutical adjuvant. the aim of this study is to evaluate the properties of the plantago major seed mucilage as a mucoadhesive agent and propranolol hydrochloride is chosen as a model drug. mucoadhesive tablets of propran...

The purpose of research work was to develop and optimize mucoadhesive microspheres of glibenclamide incorporated in in-situ gel for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy. Chitosan (mucoadhesive) based microspheres of glibenclamide were prepared by emulsificationcrosslinking method. Glutaraldehyde was used as crosslinking agent. A 32 factorial...

Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhes...