نتایج جستجو برای: multidrug resistance
تعداد نتایج: 377429 فیلتر نتایج به سال:
A large number of renal cancer patients show poor or partial response to chemotherapy and the precise mechanism has not been understood yet. MDR is the principal mechanism by which many cancers develop resistance to chemotherapeutic drugs and is associated with the elevated expression of MDR proteins. These are divided into two groups: ABC transporters and non-ABC transporters. The aim of our s...
The phenomenon of multidrug resistance implies that a wide spectrum of structurally and functionally unrelated chemotherapeutic drugs are recognized and processed by the molecular system which protects multidrug-resistant (MDR) cells against lipophilic cytotoxic drugs. This suggests that lipophilic agents with low toxicity may also be recognized and processed by this molecular system. At high c...
Microbial drug resistance is partly due to hindered diffusion through the membrane of microbial cells and active transport mechanisms. An approach to counter such resistance uses the bacterial iron transport system. Extracellular free iron is scarce in vertebrates, yet essential for microbial growth (Anderson et al., 2012). A mechanism displayed by microbial pathogens to cope with iron scarcity...
Cancer outcome has improved since introduction of target therapy. However, treatment success is still impaired by the same drug resistance mechanism of classical chemotherapy, known as multidrug resistance (MDR) phenotype. This phenotype promotes resistance to drugs with different structures and mechanism of action. Recent reports have shown that resistance acquisition is coupled to metabolic r...
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