Endoscopic band ligation without resection is a technique reported in the literature for the treatment of subepithelial neuroendocrine tumors and Barrett’s esophagus, but its use in the treatment of T1 cancer has not been reported [1–4]. We present a case of T1 esophageal cancer in a patient with contraindications for surgery treated endoscopically using banding without resection. A 74-year-old...

BACKGROUND Recognizing the significant impact of wait times for care for individuals with complex chronic conditions, we applied a LEAN methodology, namely - an adaptation of Value Stream Mapping (VSM) to meet the needs of people with multiple chronic conditions and to improve wait times without additional resources or funding. METHODS Over an 18-month time period, staff applied a patient-cen...

The patient´s survival estimate is important for clinical decision-making, especially in frail patients with multimorbidities. We aimed to develop a multidimensional geriatric prognosis index (GPI) for 3- and 5-year mortality in community-dwelling elderly and to validate the GPI in a separate hospital-based population. The GPI was constructed using data for 988 participants in the Korean Longit...

Most studies of disease etiologies focus on one disease only and not the full spectrum of multimorbidities that many patients have. Some disease pairs have shared causal origins, others represent common follow-on diseases, while yet other co-occurring diseases may manifest themselves in random order of appearance. We discuss these different types of disease co-occurrences, and use the two disea...

A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP-1/CCL2, a chemokine responsible for recruiting monocyte...

Noncommunicable diseases, including cardiovascular, metabolic and respiratory diseases, among others, are the major medical challenge of the 21st century. Most noncommunicable diseases are related to the ageing process and often co-occur in the same individual. However, it is unclear whether the index disease is somehow influencing the development of the other ones (comorbidity) or whether all ...

OBJECTIVE To examine the experiences of primary care consultation among older adults with symptomatic foot osteoarthritis (OA). METHODS Eleven participants (6 women and 5 men) ages 56-80 years who had radiographically confirmed symptomatic foot OA and consulted a general practitioner in the last 12 months for foot pain were purposively sampled. Semistructured interviews explored the nature of...

A paramount, yet unresolved issue in personalised medicine is that of automated reasoning with clinical guidelines multimorbidity settings. This entails enabling machines to use computerised generic guideline recommendations and patient-specific information yield patient-tailored where interactions arising due multimorbidities are resolved. problem further complicated by patient management desi...