نتایج جستجو برای: multiple myeloma

تعداد نتایج: 762314  

Journal: :Haematologica 2004
Joan Bladé Laura Rosiñol

Journal: :RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin 2006
M Horger H Brodoefel C Driessen

2010
Brian A. Walker Christopher P. Wardell Laura Chiecchio Emma M. Smith Kevin D. Boyd Antonino Neri Faith E. Davies Fiona M. Ross Gareth J. Morgan

2012
Sang Moon Hong Tae Wan Kim Kwan Ho Park

Multiple myeloma is a B-cell origin tumor characterized by hypercalcemia, osteolytic bony lesions, and pathologic fractures. Back pain is one of the most common presenting symptoms of multiple myeloma and about 60% of patients have vertebral involvement at the time of diagnosis7). Minimally invasive surgeries such as vertebroplasty and kyphoplasty are effective to relieve pain and improve the q...

2010
A. Jhaveri F. Muggia

This clinical vignette illustrates how our therapeutic approaches to early stages of multiple myeloma have changed over the past decade with novel therapies reducing disease and preventing disease progression. Recent paradigms of multiple myeloma describe the disease as a spectrum of clinical stages, including asymptomatic 'smoldering' states that progress to symptomatic states. The average 5-y...

2011
Nicola Giuliani Irma Airoldi

Multiple myeloma is a monoclonal postgerminal center tumor that has phenotypic features of plasmablasts and/or plasma cells and usually localizes at multiple sites in the bone marrow. The pathogenesis of multiple myeloma is complex and dependent on the interactions between tumor cells and their microenvironment. Different cytokines, chemokines, and proangiogenic factors released in the tumor mi...

2015
Jee-Yeong Jeong Michelle S Levine Nirmalee Abayasekara Nancy Berliner Jacob Laubach Gary J Vanasse

BACKGROUND Thrombocytopenia is a significant problem in patients with relapsed or refractory multiple myeloma, precipitating a need for supportive platelet transfusions and necessitating decreases in delivered doses of chemotherapy. Eltrombopag is a non-peptide, small molecule thrombopoietin (TPO) receptor agonist that promotes megakaryopoiesis similar to endogenous human TPO and may be an effe...

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