نتایج جستجو برای: multiple myeloma

تعداد نتایج: 762314  

Journal: :Cancer research 2012
Pedram Kharaziha Hendrik De Raeve Charlotte Fristedt Qiao Li Astrid Gruber Per Johnsson Georgia Kokaraki Maria Panzar Edward Laane Anders Osterborg Boris Zhivotovsky Helena Jernberg-Wiklund Dan Grandér Fredrik Celsing Magnus Björkholm Karin Vanderkerken Theocharis Panaretakis

Multiple myeloma (MM) is a B-cell malignancy characterized by the expansion of clonal plasma blasts/plasma cells within the bone marrow that relies on multiple signaling cascades, including tyrosine kinase activated pathways, to proliferate and evade cell death. Despite emerging new treatment strategies, multiple myeloma remains at present incurable. Thus, novel approaches targeting several sig...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Emanuela Leone Eugenio Morelli Maria T Di Martino Nicola Amodio Umberto Foresta Annamaria Gullà Marco Rossi Antonino Neri Antonio Giordano Nikhil C Munshi Kenneth C Anderson Pierosandro Tagliaferri Pierfrancesco Tassone

PURPOSE Deregulated expression of miRNAs plays a role in the pathogenesis and progression of multiple myeloma. Among upregulated miRNAs, miR-21 has oncogenic potential and therefore represents an attractive target for the treatment of multiple myeloma. EXPERIMENTAL DESIGN Here, we investigated the in vitro and in vivo anti-multiple myeloma activity of miR-21 inhibitors. RESULTS Either trans...

2017
Henrik Gregersen Annette Juul Vangsted Niels Abildgaard Niels Frost Andersen Robert Schou Pedersen Ulf Christian Frølund Carsten Helleberg Bettina Broch Per Trøllund Pedersen Peter Gimsing Tobias Wirenfeldt Klausen

To describe the prevalence of comorbidity and its impact on survival in newly diagnosed multiple myeloma patients compared with population controls. Cases of newly diagnosed symptomatic multiple myeloma during the 2005-2012 period were identified in the Danish National Multiple Myeloma Registry. For each myeloma patient, 10 members of the general population matched by age and sex were chosen fr...

Journal: :Cancer research 2005
Loïc Vincent David K Jin Matthias A Karajannis Koji Shido Andrea T Hooper William K Rashbaum Bronislaw Pytowski Yan Wu Daniel J Hicklin Zhenping Zhu Peter Bohlen Ruben Niesvizky Shahin Rafii

Induction of neoangiogenesis plays an important role in the pathogenesis of multiple myeloma. However, the mechanism by which expression of vascular endothelial growth factor (VEGF)-A and its receptors modulate the interaction of multiple myeloma cells with stromal cells is not known. Here, we describe a novel in vitro coculture system using fetal bone stromal cells as a feeder layer, which fac...

2005
ORHAN SEZER

Bone destruction is a hallmark of multiple myeloma, and recent studies demonstrated a strong interdependence between tumor progression and bone resorption. Increased bone resorption as a major characteristic of multiple myeloma is caused by osteoclast activation and osteoblast inhibition (uncoupling). Myeloma cells alter the local regulation of bone metabolism by increasing the receptor activat...

Journal: :Clinical Medicine 2019

Journal: :Annals of Surgery 1969

Journal: :Oncology Times 2019

Journal: :Journal of Education, Health and Sport 2022

Abstract
 
 Background: Multiple myeloma is a clonal plasma cell neoplasm which affects 1% of all malignancies. In this article we reviewed epidemiology, symptoms with particular attention to renal failure and its manifestation in multiple (MM).
 Material methods: This paper was based on medical articles collected PubMed from 2001 2022, websites books. The research has been done ...

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