OBJECTIVE We present the case of a sushi chef with pain and swelling of his index finger and wrist for a year, unresponsive to antibiotics. METHODS Biopsy showed a xanthogranulomatous reaction and positive culture results for Mycobacterium marinum. RESULTS He was treated with minocycline, clarithromycin, and ethambutol. In addition, he underwent radical synovectomy of the lesion. CONCLUSI...

Capillary zone electrophoresis (CZE) with an electrokinetically pumped sheath-flow nanospray interface was coupled with a high-resolution Q-Exactive mass spectrometer for the analysis of culture filtrates from Mycobacterium marinum. We confidently identified 22 gene products from the wildtype M. marinum secretome in a single CZE-tandem mass spectrometry (MS/MS) run. A total of 58 proteoforms we...

Hand infections occurring after fishing and other marine-related activities may involve uncommon bacteria that are not susceptible to the conventional or empiric antibiotic therapy used to treat soft tissue infections. Therefore appropriate treatment is often delayed and could lead to severe hand damage. An illustrative case of fishing-related injury leading to complicated tenosynovitis and hor...

BACKGROUND Mycobacterium ulcerans is a close derivative of Mycobacterium marinum and the agent of Buruli ulcer in some tropical countries. Epidemiological and environmental studies pointed towards stagnant water ecosystems as potential sources of M. ulcerans, yet the ultimate reservoirs remain elusive. We hypothesized that carbon substrate determination may help elucidating the spectrum of pote...

OBJECTIVE To review the epidemiology of atypical mycobacterial cutaneous infection in Hong Kong. DESIGN Retrospective study. SETTING Social Hygiene Service (Dermatology Division), the largest dermatological referral centre in Hong Kong. PATIENTS Patients with a diagnosis of atypical mycobacterial cutaneous infection based on clinical features, histopathology, with or without a positive cu...

In this study, a series of twenty-two ring-substituted 2-hydroxynaphthalene-1‑carboxanilides were prepared and characterized. Primary in vitro screening of the synthesized compounds was performed against Staphylococcus aureus, three methicillin-resistant S. aureus strains, Mycobacterium marinum, M. kasasii, M. smegmatis. and M. avium paratuberculosis. The compounds were also tested for their ac...

Mycobacterium tuberculosis remains one of the most problematic infectious agents, owing to its highly developed mechanisms to evade host immune responses combined with the increasing emergence of antibiotic resistance. Host-directed therapies aiming to optimize immune responses to improve bacterial eradication or to limit excessive inflammation are a new strategy for the treatment of tuberculos...

To cite: Iyengar KP, Matar HE, Jayeola AO, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-205443 DESCRIPTION Among infections of the hand, Mycobacterium marinum accounts for 0.04–0.27/100 000 cases; most are caused by superficial abrasions from water and other environmental sources. M. marinum has an extensive habitat and lives in a warm aquatic envi...