نتایج جستجو برای: mycophenolic acid

تعداد نتایج: 747469  

Journal: :Journal of the American Society of Nephrology : JASN 2003
William M Bennett

Over the past decade, immunosuppression for renal transplantation has shifted from predominantly azathioprine-based regimens to those containing mycophenolic acid (MMF, CellCept) (1). In most centers, MMF is combined with cyclosporine or tacrolimus (calcineurin inhibitors) plus corticosteroid therapy. These combinations have led to unprecedented patient and graft survivals over the near term (1...

Journal: :Journal of clinical pharmacology 2001
A Jain R Venkataramanan I S Hamad S Zuckerman S Zhang J Lever V S Warty J J Fung

The pharmacokinetics of mycophenolic acid (MPA) was studied after oral administration of mycophenolate mofetil (MMF) in 8 liver transplant patients. The mean (+/- SD) maximum MPA plasma concentration of 10.6 (+/- 7.5) mg/ml was achieved within 0.5 to 5 hours. The mean (+/- SD) steady-state area under the plasma concentration versus time curve (AUC(0-12)) was 40 (+/- 30.9) mg/ml/h. The mean (+/-...

Journal: :Clinical chemistry and laboratory medicine 2011
An-Sofie C Decavele Niels Favoreel Fien Vander Heyden Alain G Verstraete

BACKGROUND Mycophenolic acid (MPA) is an immunosuppressant for which therapeutic drug monitoring (TDM) is performed for optimal prophylaxis and avoidance of toxicity in transplant patients. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is ideally suited for TDM of MPA. There have been several method comparisons of the Roche Total MPA assay, but none have been performed with respect ...

2012
Carl A. Morrow Eugene Valkov Anna Stamp Eve W. L. Chow I. Russel Lee Ania Wronski Simon J. Williams Justine M. Hill Julianne T. Djordjevic Ulrike Kappler Bostjan Kobe James A. Fraser

We have investigated the potential of the GTP synthesis pathways as chemotherapeutic targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal meningoencephalitis. We find that de novo GTP biosynthesis, but not the alternate salvage pathway, is critical to cryptococcal dissemination and survival in vivo. Loss of inosine monophosphate dehydrogenase (IMPDH) in the de n...

Journal: :Evidence report/technology assessment 2008
Mark Oremus Johannes Zeidler Mary H H Ensom Mina Matsuda-Abedini Cynthia Balion Lynda Booker Carolyn Archer Parminder Raina

OBJECTIVES To investigate whether monitoring concentrations of mycophenolic acid (MPA) in the serum or plasma of persons who receive a solid organ transplant will result in a lower incidence of transplant rejections and adverse events versus no monitoring of MPA. To investigate whether the incidence of rejection or adverse events differs according to MPA dose or frequency, type of MPA, the form...

2014
Lisa Vallone Alberto Giardini Gabriella Soncini

The presence of mold in food, although necessary for production, can involve the presence of secondary metabolites, which are sometimes toxic. Penicillium roqueforti is a common saprophytic fungus but it is also the essential fungus used in the production of Roquefort cheese and other varieties of blue cheese containing internal mold. The study was conducted on industrial batches of Penicillium...

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