نتایج جستجو برای: mycophenolic acid

تعداد نتایج: 747469  

2012
Diego Muñoz-Torrero Diego Haro Joan Vallès Helena Colom Nuria Lloberas Ana Caldés Franc Andreu Joan Torras Jaime Sanchez-Plumed Miguel A. Gentil Dirk R. Kuypers Mercé Brunet Henrik Ekberg Josep M. Grinyó

Mycophenolate mofetil (MMF), an ester prodrug of the immunosuppressant mycophenolic acid (MPA), is widely used for maintenance immunosuppressive therapy and prevention of renal allograft rejection in renal transplant recipients. MPA inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in the “de novo” synthesis of purine nucleotides, thus suppressing both T-cell and B-cell p...

2014
Tim Ulinski Aurélie Davourie-Salandre Isabelle Brocheriou Bilal Aoun

We report the case of an 11-year-old previously healthy girl who presented for microscopic hematuria and nephrotic proteinuria with normal renal function, which persisted after 6 months of steroids, angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers, hydroxychloroquine, mycophenolic acid and a low-salt diet. A serum investigation suggested lupus nephritis and a renal ...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2010
Petra Glander Claudia Sommerer Wolfgang Arns Toofan Ariatabar Stefan Kramer Eva-Maria Vogel Maria Shipkova Wolfgang Fischer Martin Zeier Klemens Budde

BACKGROUND AND OBJECTIVES Adequate early mycophenolic acid (MPA) exposure is an important determinant for effective rejection prophylaxis. This pharmacokinetic study investigated whether an intensified dosing regimen of enteric-coated mycophenolate sodium (EC-MPS) could achieve higher mycophenolic acid (MPA) exposure early after transplantation versus a standard dosing regimen. DESIGN, SETTIN...

2017
Ji-Yeun Chang Jihyun Yu Byung Ha Chung Jaeseok Yang Sung-Joo Kim Chan-Duck Kim Sang-Ho Lee Jong Soo Lee Joong Kyung Kim Cheol Woong Jung Chang Kwon Oh Chul Woo Yang

BACKGROUND The actual prescription pattern of immunosuppressive agents in kidney transplantation is unclear. METHODS We investigated the pattern and trend of immunosuppressive treatment for kidney transplant patients in South Korea. A total of 636 patients at nine transplant centers were enrolled and followed for one year. We reviewed medical records and evaluated induction therapy, as well a...

2006
John Yu Victor Lemas Theodore Page James D. Connor Alice L. Yu

The effects of three inhibitors of inosine monophosphate (IMP) dehydrogenase on a human erythroleukemic cell line, K562, were studied. Following incubation with these inhibitors, K562 cells underwent differ entiation and accumulated hemoglobins. The induction of hemoglobin accumulation was dose dependent; maximum induction was observed at 100, 25, and 3 MM,respectively, for ribavirin, tiazofuri...

Journal: :Molecules 2007
Guillermo Schmeda-Hirschmann Carlos Aranda Marcela Kurina Jaime A Rodríguez Cristina Theoduloz

Microbial transformation of imbricatolic acid (1) by Aspergillus niger afforded 1alpha-hydroxyimbricatolic acid (2), while transformation with Rhizopus nigricans yielded 15-hydroxy-8,17-epoxylabdan-19-oic acid (3). When the diterpene 1 was added to a Cunninghamella echinulata culture, the main products were the microbial metabolites mycophenolic acid (4) and its 3-hydroxy derivative 5. All the ...

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