نتایج جستجو برای: mycophenolic acid

تعداد نتایج: 747469  

2013
Ana M. Ortega-Prieto Julie Sheldon Ana Grande-Pérez Héctor Tejero Josep Gregori Josep Quer Juan I. Esteban Esteban Domingo Celia Perales

Lethal mutagenesis, or virus extinction produced by enhanced mutation rates, is under investigation as an antiviral strategy that aims at counteracting the adaptive capacity of viral quasispecies, and avoiding selection of antiviral-escape mutants. To explore lethal mutagenesis of hepatitis C virus (HCV), it is important to establish whether ribavirin, the purine nucleoside analogue used in ant...

Journal: :Canadian journal of microbiology 1973
R W Detroy S N Freer D I Fennell

DETRO)", R, \\"., S. N. FREER, and D. I. FEC;C;ELL. 1973. Relationship betwcen the biosynthesis of viruslike panic!cs and mycophenolic acid in Pellicillilllll s!olonifertlli1 and Penicillium hrel'i-compaCfIlIll. Can. J. ivlicrobiol. 19: 1459-1462. Several strains of Penieillilllll s!olonZrerll'n and P. breci-compaCI/ll1l containing no virus-like particles (YLP) synthesize mycophenolic acid (MAl...

Journal: :The Journal of antibiotics 1968
K Ando S Suzuki G Tamura K Arima

Journal: :The Journal of antibiotics 1969
T Noto M Sawada K Ando K Koyama

Mycophenolic acid (MA) inhibits the growth of some pathogenic fungi such as Candida albicans, Cryptococcus neoformans and several species of Trichophyton at low concentrations in vitro. The antibiotic is more effectvie against fungi at slightly acidic pH than neutral pH. When administered to mice through the intraperitoneal, intramuscular and oral routes MA excreted toafewper cent in the urine....

Journal: :The Journal of antibiotics 1976
S Suzuki S Takaku T Mori

One hundred and eight derivatives of mycophenolic acid (MA) have been prepared by modifications at the phenolic hydroxyl and/or carboxyl sites. None of these compounds was as effective as MA in suppressing cell growth of L-518Y cell in vitro, whereas several compounds with changes at both the hydroxyl and carboxyl groups were more effective than MA against Ehrlich solid carcinoma and L-1210 leu...

Journal: :Cancer research 1987
R H Lipsky S J Silverman

Expression of glial fibrillary acidic protein (GFAP) was assayed in 11 glioma-derived cell cultures. Treatment of cells with an inhibitor of guanine nucleotide biosynthesis, mycophenolic acid, enhanced detection of GFAP by indirect immunofluorescence microscopy. Quantitation of GFAP and vimentin demonstrated that enhanced fluorescence occurs without an increase in the level of intermediate fila...

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