Myelin associated glycoprotein (MAG) is an essential component of the periaxonal architecture of the myelin sheath. Because of its potent neurite growth repressive activity, MAG is also likely to play an important role in axonal guidance during the CNS development, and to be responsible for abortive neuronal regeneration in adult CNS. The MAG gene chromatin from approximately 1.6 to +0.6 kb fea...

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system (CNS) in young adults. Chronic treatments with histone deacetylase inhibitors (HDACis) have been reported to ameliorate experimental autoimmune encephalomyelitis (EAE), a rodent model of MS, by targeting immune responses. We have recently shown that the HDAC inhibition/knockdown i...