Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) or aquaporin 4 (AQP4-IgG) are associated with CNS inflammatory disorders. We directly compared MOG35-55-induced experimental autoimmune encephalomyelitis exacerbated by MOG- and AQP4-IgG (versus isotype IgG, Iso-IgG). Disease severity was highest after MOG-IgG application. administration increased disease incidence Iso-IgG. Inflammator...

Neurofibromatosis 1 is a common autosomal dominant disease that principally involves the skin and peripheral nervous system. The gene for the disorder has been located on chromosome 17q11.2 and there are three embedded genes within the neurofibrosis gene. One of these genes codes for oligodendrocyte-myelin glycoprotein, is found in the CNS during myelination, and may have a role in myelin forma...

During the development of experimental autoimmune encephalomyelitis (EAE), the proportion of pathogenic and myelin-specific cells within CNS-infiltrating cytokine-producing Th cells is unknown. Using an IL-17A/IFN-γ double reporter mouse and I-A(b)/myelin oligodendrocyte glycoprotein 38-49 tetramer, we show in this study that IL-17(+)IFN-γ(+) Th cells, which are expanded in the CNS during EAE, ...

Two putative human oligodendroglioma cell lines were examined for the expression of the oligodendrocyte-associated genes, 2',3'-cyclic nucleotide-3'-phosphodiesterase, myelin basic protein, myelin proteolipid proteins, and myelin-associated glycoprotein. The expression of these genes also was examined in control astrocytoma and neuroblastoma cell lines. In addition, the expression of the non-ol...

OBJECTIVE Intrathecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B-cell clonal expansion are well-characterized features of the humoral response in multiple sclerosis (MS). Nevertheless, the target antigen of this response remains enigmatic. METHODS We produced 53 different human IgG1 monoclonal recombinant antibodies (rAbs) by coexpressing paired heavy- and light-chai...

After injury to the central nervous system (CNS) in adults, axonal regeneration is confined, in part, by the inhibitory factors in CNS myelin, including Nogo-A protein, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMGP). These proteins, all bind to the same neuronal glycosylphosphatidylinositol-anchored receptors (NgR), and transduce inhibitory signals to cells ...

The adult CNS is an inhibitory environment for axon outgrowth, severely limiting recovery from traumatic injury. This limitation is due, in part, to endogenous axon regeneration inhibitors (ARIs) that accumulate at CNS injury sites. ARIs include myelin-associated glycoprotein, Nogo, oligodendrocyte-myelin glycoprotein, and chondroitin sulfate proteoglycans (CSPGs). Some ARIs bind to specific re...