conclusions the growth rate of information in bioinformatics databases could facilitate studies of live organisms prior to observation studies. two different protein classes could be causative agents of one disease. however, two related diseases from one disease group could consist of different protein classes. future research in the field of proteomics could allow modern insight to reshuffling...

Growth arrest specific 3 (Gas3)/peripheral myelin protein 22 (PMP22) is a component of the compact peripheral nerve myelin, and mutations affecting gas3/PMP22 gene are responsible for a group of peripheral neuropathies in humans. We have performed in vivo imaging in order to investigate in detail the phenotype induced by Gas3/PMP22 overexpression in cultured cells. Here we show that Gas3/PMP22 ...

Myelin oligodendrocyte glycoprotein (MOG), a member of the immunoglobulin (Ig) superfamily, is myelin protein expressed at outermost lamellae sheaths and oligodendrocytes (OGD) memb...

In severe COVID-19 patients the blood level of autoantibodies (IgG) to neurospecific proteins was determined. It defined marked increase in peripheral myelin protein, protein lipid S100 type 2 dopamine receptors and dopamine. At same time, it designate relationship between levels NMDA receptors. High specific IgG SARS-CoV-2 S-Trimer Protein coincided with high

BACKGROUND SH3TC2, PMP2, and BSCL2 genes are related to autosomal recessive (AR) Charcot-Marie-Tooth (CMT) disease type 1, autosomal dominant (AD)-CMT1, and AD-CMT2, respectively. Pathogenic variants in these three genes were not well documented in Chinese CMT patients. Therefore, this study aims to detect SH3TC2, PMP2, and BSCL2 pathogenic variants in a cohort of 315 unrelated Chinese CMT fami...

objective(s) erythropoietin has been shown to exert neuroprotective effects in a variety of cns injury models. elevation of serum s100β, as a glial damage marker and myelin basic protein (mbp) has been reported to occur in acute carbon monoxide (co) poisoning. the aim of this study was to evaluate the effect of erythropoietin (epo) on serum s100β and mbp levels after co poisoning in rats. mater...

Myelination was studied in aggregating cell cultures derived from mechanically 15- to 16-day fetal rat brains. Myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) were localized immunocytochemically 20-micrometers-thick Vibratome 1-micrometer- thick Epon sections at 15, 20, 25, 30 days vitro. The occurrence of these proteins correlated with the ultrastructural appearance oligode...

Oligodendroglia growth factor (OGF) is a 16-kDa soluble protein produced by neuronal cell lines. This factor, when incubated with brain glia in culture, selectively stimulates growth of oligodendroglia, the myelin-producing cells of the CNS. OGF infused into the cerebral cortex of the adult rat accelerates the production of myelin proteins as shown by increased specific activity of the myelin e...