We developed several novel tools to genome wide screen for CNVs and SNPs in single cells. When applied to cleavage stage embryos from young fertile couples we discovered, unexpectedly, an extremely high incidence of chromosomal instability, a hallmark of tumorigenesis (Vanneste et al., Nature Medicine, 2009; Vanneste et al., Hum.Reprod., 2011). Not only mosaicisms for whole chromosome aneuploid...

The main objective of this paper is to investigate the distribution Andrews-Garvan-Dyson cranks partitions. Let M(m,n) denote number partitions n with crank m, we show that sequence {M(m,n)}|m|≤n−1 unimodal for n≥44. It turns out unimodality related monotonicity properties two partition functions pr(n) and ppr(n). parts taken from {2,3,…,r} let ppr(n) pairs (α,β) partitions, where α a counted b...

Scandium-44 (t1/2 = 3.9 h) is a relatively new radioisotope of potential interest for use in clinical positron emission tomography (PET). Herein, we report, for the first time, the room-temperature radiolabeling of proteins with (44)Sc for in vivo PET imaging. For this purpose, the Fab fragment of Cetuximab, a monoclonal antibody that binds with high affinity to epidermal growth factor receptor...