In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) forms involved in the oxidative metabolism of [14C]ABT-761 and its N-dehydroxylated metabolite, [14C]ABT-438, by human liver microsomes. The two compounds were metabolized by parallel pathways, to form the corresponding methylene bridge hydroxy metabolites. There was no evidence of sulfoxidation and/or ring hydroxylat...

BACKGROUND TAK-438 (vonoprazan) is a potassium-competitive acid blocker that reversibly inhibits gastric H(+) , K(+) -ATPase. AIM To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-438 in healthy Japanese and non-Japanese men. METHODS In two Phase I, randomised, double-blind, placebo-controlled studies, healthy men (Japan N = 60; UK N = 48) received TAK-438 1...

Proton pump inhibitors (PPIs) are widely used in the treatment of acid-related diseases. However, several unmetmedical needs, suchas suppression of night-time acid secretion and rapid symptom relief, remain. In this study, we investigated the pharmacologicaleffects of 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel<l...

Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related diseases. However, several medical needs such as suppression of night-time acid secretion and rapid symptom relief remain unmet. In this study, we investigated the effects of 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel potassium-competitive acid ...

Proton pump inhibitors (PPIs) are widely used in the treatment of acid-related diseases. However, several unmet medical needs, such as suppression of night-time acid secretion and rapid symptom relief, remain. In this study, we investigated the pharmacological effects of 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel potassium-...

BACKGROUND Adults over age 40 are increasing their use of email and social media, raising interest in use of peer-to-peer Internet-based messaging to promote cancer screening. OBJECTIVE The objective of our study was to assess current practices and attitudes toward use of email and other e-communication for peer-to-peer dialogues on cancer screening. METHODS We conducted in-person interview...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 3 423–437 www.jcb.org/cgi/doi/10.1083/jcb.200811083 JCB 423 Correspondence to Richard D. Kolodner: [email protected] J.M. Enserink’s present address is Dept. of Molecular Biology, Rikshospitalet University Hospital, NO-0027 Oslo, Norway. Abbreviations used in this paper: CKI, Cdk inhibitor; CPT, camptothecin; DSB, DNA double-st...

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Prescribed fires are used to manipulate and manage rangelands, but effective monitoring techniques are needed to ensure that management goals and objectives are being met. The application of an effective fire program on rangelands is not a simple task. Overgrazing by livestock since the early development of the livestock industry has altered the vegetative complex on most rangelands with an inc...