Meningococcal disease occurs as sporadic cases in developed countries, with the occasional emergence of new clones of Neisseria meningitidis. Here, we report the genome sequence of N. meningitidis strain LNP27256, an isolate of sequence type 11 linked to a recent outbreak among men who have sex with men in Europe.

In 2012, Neisseria meningitidis serogroup W caused a widespread meningitis epidemic in Burkina Faso. We describe the dynamic of the epidemic at the subdistrict level. Disease detection at this scale allows for a timelier response, which is critical in the new epidemiologic landscape created in Africa by the N. meningitidis A conjugate vaccine.

Among 384 patients with confirmed meningococcal disease, the likelihood of detecting Neisseria meningitidis DNA in cerebrospinal fluid (CSF) increased with age, serogroup B infection, and prehospitalization antibiotic treatment. Plasma and CSF genomic bacterial loads of non-B N. meningitidis serogroups correlated significantly. Serogroup B-infected patients with genotype TNF2 (-308A) had signif...

A cluster of 18 open reading frames (ORFs), 15 of which are homologous to genes involved in division and cell wall synthesis, has been identified in Neisseria gonorrhoeae and Neisseria meningitidis. The three additional ORFs, internal to the dcw cluster, are not homologous to dcw-related genes present in other bacterial species. Analysis of the N. meningitidis strain MC58 genome for foreign DNA...

OBJECTIVES We sought to describe Neisseria meningitidis immunity and its association with pharyngeal carriage in Burkina Faso, where N. meningitidis serogroup W-135 and serogroup A disease are hyperendemic and most of the population received polysaccharide A/C vaccine during 2002. METHODS We collected oropharyngeal swab samples from healthy residents of Bobo-Dioulasso (4-14 years old, n=238; ...

Background: Neisseria meningitidis and Staphylococcus aureus usually carried without symptoms in nasopharynx, but carriage of these pathogens can lead to serious infectious diseases in children. Meningitis beyond the neonatal period caused by N. meningitidis remains the main reason for morbidity and mortality among children in developing countries. The aim of the study was to assess nasopharyng...

In Oregon and parts of Washington State, the incidence of serogroup B meningococcal disease increased substantially in 1994 (1). Multilocus enzyme electrophoresis (MEE) subtyping of N. meningitidis serogroup B strains collected in these areas during 1993 and 1994 suggested that these increases were due to a group of genetically related strains of the enzyme type-5 (ET-5) complex. ET-5 N. mening...

Six atypical aerobic gram-negative cocci, isolated from humans, were classified taxonomically by genetic relatedness (DNA base pairs and DNA homology), fatty acid content, pigment absorption profile, and other physiological and biochemical characteristics. One strain (M448), which produced acid only from glucose, was identified as Neisseria meningitidis; one strain (CH), which produced acid fro...

Objective: To describe the epidemiology of bacterial meningitis in Niger from January 2002 to June 2010 Methods: A retrospective study of data from the laboratory surveillance of meningitis; cerebrospinal fluid samples from suspected clinical cases were collected and tested using polymerase chain reaction and/or bacteriology for the surveillance of bacterial meningitis in Niger. Data on patient...