Moller-Plesset second-order (MP2) perturbation theory remains the least expensive standard ab initio method that includes electron correlation, scaling as O(N5) with the number of molecular orbitals N. Unfortunately, when restricted Hartree-Fock orbitals are employed, the potential energy curves calculated with this method are of little use at large interatomic separations because of the diverg...

To induce differentiation of embryonic stem cells (ESCs) into specialized cell types for therapeutic purposes, it may be desirable to combine genetic manipulation and appropriate differentiation signals. We studied the induction of dopaminergic (DA) neurons from mouse ESCs by overexpressing the transcription factor Nurr1 and coculturing with PA6 stromal cells. Nurr1-expressing ESCs (N2 and N5) ...

different resource of fertilizers had an effect on grain yield, oil and grain quality. information regarding the effect of simultaneous application of organic, chemical and biological fertilizers on canola (brassica napus l.) traits is not available. in order to study the effect of different systems of soil fertility on grain yield and quality of canola (talayeh cultivar), an experiment was con...

The free radicals that people face in their daily activities require humans to get additional antioxidants from the outside. To overcome this problem, it is necessary look for many sources of natural considering need are increasingly needed Katimaha (K. hospita L.) believed have benefits field medicine. Therefore, katimaha has potential be used as a source antioxidants. research methods carried...

In cobaiamin deficiency, inadequate DNA-thymine synthesis appears to resuit from decreased conversion of N5methyltetrahydrofolic acid to tetrahydrofo ic acid (THE). The N5-methyl THE conversion catalyzed by N5methyl THF-homocysteine methyltransferase requires a cobalamin coenzyme, presumed to be methylcobalamin (methyl-B12). In support of the above, in B12-deficient marrow cultures, methyl-B12 ...

Gender differences in the development of children’s and adolescents’ academic self-perceptions have received increasing attention in recent years. This study extends previous research by examining the development of mathematics self-concept across grades 7–12 in three cultural settings: Australia (Sydney; N5 1,333), the United States (Michigan; N5 2,443), and Germany (four federal states; N5 4,...

The protein microenvironment surrounding the flavin cofactor in flavoenzymes is key to the efficiency and diversity of reactions catalysed by this class of enzymes. X-ray diffraction structures of oxidoreductase flavoenzymes have revealed recurrent features which facilitate catalysis, such as a hydrogen bond between a main chain nitrogen atom and the flavin redox center (N5). A neutron diffract...

Both language and music consist of sequences that are structured according to syntactic regularities. We used two specific event-related brain potential (ERP) components to investigate music-syntactic processing in children: the ERAN (early right anterior negativity) and the N5. The neural resources underlying these processes have been posited to overlap with those involved in the processing of...

Human and animal studies indicate that k-opioid receptors (KORs) are involved in ethanol drinking and dependence (Xuei et al., 2006; Walker and Koob, 2008; Walker et al., 2011). Using in vitro singlecell recording techniques in mouse brain slices, we examined the physiologic effects of KOR activation in the central amygdala (CeA) on GABAergic neurotransmission and its interaction with acute eth...

Cholesterol oxidase (CO) is a flavoenzyme that catalyzes the oxidation and isomerization of cholesterol to cholest-4-en-3-one. The reductive half reaction occurs via a hydride transfer from the substrate to the FAD cofactor. The structures of CO reduced with dithionite under aerobic conditions and in the presence of the substrate 2-propanol under both aerobic and anaerobic conditions are presen...