The highly diverse Numb-associated kinase (NAK) family has been linked to broad cellular functions including receptor-mediated endocytosis, Notch pathway modulation, osteoblast differentiation, and dendrite morphogenesis. Consequently, NAK kinases play a key role in a diverse range of diseases from Parkinson's and prostate cancer to HIV. Due to the plasticity of this kinase family, NAK kinases ...

VIDEO ABSTRACT During development, dendrites arborize in a field several hundred folds of their soma size, a process regulated by intrinsic transcription program and cell adhesion molecule (CAM)-mediated interaction. However, underlying cellular machineries that govern distal higher-order dendrite extension remain largely unknown. Here, we show that Nak, a clathrin adaptor-associated kinase, pr...

PURPOSE To review the involvement of the ion transporter Na+/K+-ATPase (NaK) in the migration and proliferation of glioma cells. Preliminary studies indicate that NaK alpha1 subunits seem to be upregulated in a proportion of glioblastomas but not in normal brain tissues. DESIGN The present review focuses on (1) the natural resistance of migrating malignant glioma cells to apoptosis, (2) autop...

Fundamental concepts governing ion selectivity in narrow pores are reviewed and the microscopic factors responsible for the lack of selectivity of the NaK channel, which is structurally similar to the K+-selective KcsA channel, are elucidated on the basis of all-atom molecular dynamics free energy simulations. The results on NaK are contrasted and compared with previous studies of the KcsA chan...

Glucocorticoids are commonly used as palliative or chemotherapeutic clinical agents for treatment of a variety of cancers. Although steroid treatment is beneficial, the mechanisms by which steroids improve outcome in cancer patients are not well understood. Na,K-ATPase beta-subunit isoform 1 (NaK-β1) is a cell-cell adhesion molecule, and its expression is down-regulated in cancer cells undergoi...

BACKGROUND The negative factor (Nef) of human and simian immunodeficiency viruses (HIV-1, HIV-2 and SIV) is required for high levels of viremia and progression to AIDS. Additionally, Nef leads to cellular activation, increased viral infectivity and decreased expression of CD4 on the cell surface. Previously, we and others demonstrated that Nef associates with a cellular serine kinase (NAK) acti...

The fluorescent unnatural amino acid, (7-hydroxycoumarin-4-yl)ethylglycine (HC), was site-specifically incorporated at the Phe69 site, close to the entrance of the selectivity filter of the NaK channel. Decreased fluorescence lifetime and elevated time-resolved anisotropy of NaK-F69HC in buffers with high K(+)/Na(+) molar ratios indicated the K(+) preference at the entrance of the NaK channel, ...

Bu makalede Osmanl? Devleti’nde din ve mezhep anlay???nda Nak?ibendiyye tarikat?n?n önemi incelenmi?tir. Konunun kapsaml? bir ?ekilde ortaya konulmas? için önce Osmanl?’n?n kurulu?u devresinde tasavvuf temelinde ?slam’?n etkisine i?aret edilmi?, sonra da tarikat? temel esaslar? hakk?nda bilgi verilmi?tir. Makalede Nak?ibendiyye’nin Osmanl?’ya ilk olarak ne zaman geldi?i ara?t?r?lm?? bu çerçeved...

One of the most important technical problems in reliable multicast protocol is reducing redundant NAKs to avoid NAK implosion. A number of NAK suppression mechanisms have been proposed to deal with this problem. In the MBONE, which is a virtual multicast network and makes multi-point communication across the Internet feasible, the source link, the links directly connected to or very close to th...