Neoadjuvant chemotherapy (NAC) has become a standard therapy for patients with advanced breast cancer. Pathological complete response (pCR) after NAC is an important prognostic indicator, but some patients with pCR continue to experience recurrence. So new predictive and prognostic markers in addition to pCR are needed following NAC for breast cancer. Fluorodeoxyglucose positron emission tomogr...

Objective: Sarcopenia, or the age-related loss of skeletal muscle mass and function, has been investigated as a potential marker of adverse outcomes among surgical patients. Our aim was to assess for changes in psoas muscle volume (PMV) following administration of neoadjuvant chemotherapy (NAC) in patients with bladder cancer and to examine whether changes in PMV following NAC are predictive of...

BACKGROUND To assess the efficacy of neoadjuvant chemotherapy (NAC) in esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy (CRT). METHODS The clinical data of patients with ESCC treated with chemoradiotherapy with or without NAC were collected and retrospectively reviewed. The overall survival, locoregional failure-free survival, and distant failure-fr...

objective: glutamate is considered a target for treating obsessive-compulsive disorder (ocd). the efficacy and safety of the nutritional supplement of n-acetylcysteine (nac) as an adjuvant to serotonin reuptake inhibitor (ssri) for treating children and adolescents with ocd has never been examined. methods: this was a 10-week randomized double-blind placebo-controlled clinical trial with 34 ocd...

background: using human skin-fibroblast cell line hf2ff, the efficacy of some drugs was evaluated against sulfur mustard (sm) cytotoxicity. the drugs were the sulfhydryl containing molecule including n-acetylcysteine (nac), 2-oxo-thiazolidine-4-carboxylate (otc) and acetaminophen as glutathione (gsh) stimulator pathway. methods: the protective effects of nac (0.1 mm), otc (1.8 mm), and acetamin...

Sepsis is a common cause of acute kidney injury (AKI) and acute lung injury. Oxidative stress plays as important role in such injury. The aim of this study was to evaluate the effects that the potent antioxidant N-acetylcysteine (NAC) has on renal and pulmonary function in rats with sepsis. Rats, treated or not with NAC (4.8 g/l in drinking water), underwent cecal ligation and puncture (CLP) 2 ...

rifampin, an antibiotic widely used for the treatment of mycobacterial infections, produceshepatic, renal and bone marrow toxicity in human and animals. in this study, the protectiveeffects of vitamin c and n-acetylcysteine (nac) on the toxicity of rifampin on hepg2 cellswere investigated.human hepatoma cells (hepg2) were cultured in 96-well m of rifampin in the presence ofmicroplate and expose...

introduction: 3-4, methylenedioxymethamphetamine (mdma) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to mdma-induced neurotoxicity. the aim of this study is to examine the effects of n-acetyl-l-cystein (nac) as an antioxidant on mdma-induced apoptosis. methods: 21 sprague dawley male rats (200-250mg) were treated with mdma (2×0,5mg/kg) or mdma...