The acidic extracellular environment of tumors potentiates their aggressiveness and metastasis, but few methods exist to selectively modulate the extracellular pH (pHe) environment of tumors. Transient flushing of biological systems with alkaline fluids or proton pump inhibitors is impractical and nonselective. Here we report a nanoparticles-based strategy to intentionally modulate the pHe in t...

We compared the effectiveness of calcium acetate as a phosphate binder with that of calcium carbonate by substituting one for the other in patients undergoing continuous ambulatory peritoneal dialysis. Twenty patients who had been receiving calcium carbonate as a phosphate binder were instead given calcium acetate, initially with two thirds of the previous dose of elemental calcium. The calcium...

Concentrations of minor (Mg and Sr) and trace (Ba and U) elements in four natural calcium carbonate samples were first analyzed by inductively coupled plasma mass spectrometry (ICP-MS) after chemical dissolution and calibrated against a standard dolomite. Their homogeneities were checked by in situ laser ablation (LA) ICP-MS with 10-20 spots. The carbonate samples were measured by using a high ...

Calcium carbonate forms scales, geological deposits, biominerals, and ocean sediments. Huge amounts of carbon dioxide are retained as carbonate ions, and calcium ions represent a major contribution to water hardness. Despite its relevance, little is known about the precipitation mechanism of calcium carbonate, and specified complex crystal structures challenge the classical view on nucleation c...

INTRODUCTION In hypoparathyroidism, calcium supplementation using calcium carbonate is necessary for the hypocalcemia control. The best calcium carbonate intake form is unknown, be it associated with feeding, juice or in fasting. OBJECTIVE The objective was to evaluate the calcium, phosphorus and Calcium×Phosphorus product serum levels of hypoparathyroidism women after total thyroidectomy, fo...

Oyster shells have received attention for use as a calcium resource. For this study, calcium phosphate was prepared from phosphoric acid and oyster shells. The influences of the concentration of phosphoric acid and pH in the preparation conditions were studied from the yields of calcium phosphate and unreacted carbonate, and the Ca/P ratios in precipitates. The yield of calcium phosphate and ca...

A mechanism of the transport of nanocrystalline doped calcium carbonatephosphates through the membrane on the model of interaction with phospholipids is considered. Nanocrystalline doped calcium carbonate – phosphates are perspective to transport of the cations in a living cell. Kinetics of the synthesis of nanocrystalline doped calcium carbonatephosphates are non-linear kinetics. Biomaterial b...

Background: The salt tolerance of halophilic bacteria make them promising candidates for technical applications, like isolation of salt tolerant enzymes or remediation of contaminated saline soils and waters. Furthermore, some halophilic bacteria synthesize inorganic solids resulting in organic–inorganic hybrids. This process is known as biomineralization, which is induced and/or controlled by ...

Recent dietary life involves frequent opportunities for the ingestion of purified, processed food products and preserved foods, and it has been pointed out that the current dietary mineral intake strongly tends toward nutritional imbalance. The Ryukyu Islands yield coral which contains calcium and magnesium in a content ratio of about 2 to 1, with their approximate contents of 20 and 10%, respe...

We demonstrate a novel approach for synthesizing porosity-controlled calcium carbonate by one-step thermal decomposition of various calcium carboxylate derivatives as well as their mixtures with different molar ratios. By varying the volume content of calcium in the calcium compounds or mixtures, the resulting porous calcium carbonate exhibits distinct porosity and structures that are very prom...