Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and...

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that commonly used for arthritis, gout, and other musculoskeletal disorders. poorly soluble in water according to the biopharmaceutical classification system (BCS) classified as Class II with good permeability but poor dissolution. The self-nanoemulsifying delivery (SNEDDS) has been extensively employed improve dissolution absorption o...

In the present work a new indomethacin (IND) self-nanoemulsifying drug delivery formulation (SNEDDF) have been prepared to enhance its dissolution which in turn could provide a better chance for IND oral absorption. IND SNEDDF have been prepared using different concentrations of castor oil as a solvent for IND, Cremophor RH 40 (Cr-40) as surfactant and Capmul MCM-C8 (Ca-8) as co-surfactant. Dro...