Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assor...

Background: The effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) and nanoscaffolds were evaluated in enhancing wound healing irradiated albino rats. Methods: Sixty-four male rats subjected to 6 grays (Gy) gamma (γ)-rays. Surgical wounds created on the rats’ backs they randomly assigned one four groups (16 each); these an control group, which did not receive treatment, NS group tre...

The endothelium monolayer lining in the luminal side of blood vessels provides critical antithrombotic functions. Damage to these cells will expose a highly thrombogenic subendothelium, which leads to pathological vascular changes. Using combined tissue engineering and ligand-receptor targeting strategy, we developed a biodegradable urethane-doped polyester (UPE) multifunctional targeting nanop...

This paper reports the utilization of capillary microfluidics to rapidly create nanostructure-patterned electrodes for energy storage applications. Using patterned photoresist as open-channel capillary microfluidics, Tobacco mosaic virus (TMV) bio-nanoscaffolds suspended in solution are autonomously delivered onto planar gold electrodes over a 1 cm2 area. The TMVs assemble on the electrode and ...