Aims/Objective: To formulate and evaluate RGD sequenced fibrin/fibrinogen based nanoscaffolds (acid-labile linker) for the treatment of brain tumor targeting to achieve an acid-triggered drug release under a mild acidic condition in tumor.
 Place Duration Study: Department Pharmaceutics, Parul Institute Pharmacy Research, University, Vadodara, between 2017 2021.
 Methodology: Nanoscaf...

Lubricant-infused surfaces (LIS) are highly efficient in repelling water and constitute a very promising family of materials for condensation processes occurring broad range energy applications. However, the performance LIS such is limited by inherent thermal resistance imposed thickness lubricant supporting surface structure, as well gradual depletion over time. Here, we present an ultrathin (...

The fast-developing field of RNA nanotechnology requires the adoption and development of novel and faster computational approaches to modeling and characterization of RNA-based nano-objects. We report the first application of Elastic Network Modeling (ENM), a structure-based dynamics model, to RNA nanotechnology. With the use of an Anisotropic Network Model (ANM), a type of ENM, we characterize...

DNA nanotechnology has reported a wide range of structurally tunable scaffolds with precise control over their size, shape and mechanical properties. One promising application these nanodevices is as probes for protein function or determination structure. In this perspective we cover several recent examples in field, including determining the effect ligand spacing multivalency on cell activatio...