In this study, optimized freeze-dried finasteride nanoparticles (NPs) were prepared from drug nanosuspension formulation that was developed using the bottom-up technique. The effects of four formulation and processing variables that affect the particle size and solubility enhancement of the NPs were explored using the response surface optimization design. The optimized formulation was morpholog...

BACKGROUND Nanocrystals have the potential to substantially increase dissolution rate, solubility with subsequent enhanced bioavailability via the oral route of a range of poor water soluble drugs. Regardless of other issues, scale up of the batch size is the main issue associated with bottom up approach. MATERIAL AND METHODS Smart nanocrystals of artemisinin (ARM) was produced relatively at ...

Nanosuspension is a novel drug formulation for the delivery of hydrophobic drugs. The problem medications that are poorly water-soluble and have low bioavailability countered by nanosuspension technology. Solubility significant physiochemical element influences absorption therapeutic effectiveness. Poor aqueous solubility has potential to impair development. technology can improve drug's stabil...

BACKGROUND AND THE PURPOSE OF THE STUDY Lamotrigine (LMG) undergoes extensive hepatic metabolism upon oral administration and its absorption is affected in the presence of food. This study was aimed to develop nanosuspension of LMG and investigate its formulation characteristics using L(9) orthogonal array. METHODS Nanosuspension was prepared using emulsification-solvent diffusion method. All...

Background: The aim of this study is to formulate nanosuspension Scoparia dulcis. This plant species mainly used as an analgesic, antipyretic, and urinary issues well stomach disorders, kidney stones, hypertension, diabetes, inflammation. In alcoholic extracts dulcis are used. ionic gelation method the most suitable polyherbal nanosuspension. Methods: Herbal was prepared by emulsion method. Chi...

BCS class II drugs associated as they are with low aqueous solubility and bioavailability pose an alarming challenge for the pharmaceutical scientists from the point of view of formulation by conventional methods. That is all the more surprising as around forty percent of the new generated drugs exhibit poor water solubility. However , the formulation of such drugs is now being increasingly don...

Asthma and chronic obstructive pulmonary disease (COPD) are pulmonary diseases that are characterized by inflammatory cell infiltration, cytokine production, and airway hyper-reactivity. Most of the effector cells responsible for these pathologies reside in the lungs. One of the most direct ways to deliver drugs to the target cells is via the trachea. In a pre-clinical setting, this can be achi...

Clarithromycin (CLM) is a member of macrolide family with broad spectrum antibiotic activity. It is practically insoluble in water and its poor solubility is pH dependent. In this study, series of nanosuspensions containing CLM and stabilizer such as HPMC, NaCMC, polysorbate 80, poloxamer 188 and polyvinyl alcohol in various ratios were prepared using sonoprecipitation method. Briefly, CLM was ...

AIM Quantitative estimation of lercanidipine HCl in bulk material as well as from nanosuspension formulations via a developed reverse phase HPLC method. MATERIALS AND METHODS Optimized chromatographic condition was used to achieve separation on a Kromasil (100-5c18 250 × 4.6 mm) column using Shimadzu HPLC system. The mobile phase consisted of a mixture of acetate buffer (20 mM pH 4.5) and ace...

Drug nanosuspensions have gained tremendous attraction as a platform in drug delivery. In the present work, a nanosuspension was prepared by a wet milling approach in order to increase saturation solubility and dissolution of the water insoluble drug, hydrocortisone. Size of the generated particeles was 290 nm ± 9 nm having a zeta potential of -1.9 mV ± 0.6 mV. Nanosized particles were found to...