Poor aqueous solubility of lead drug candidates remains an obstacle for drug development in pharmaceutical industries. Drugs with dissolution rate limited drug absorption show low bioavailability due to poor aqueous solubility of the drug. To overcome these problems different formulations of nanosized drugs were developed recently. Pharmaceutical nanosuspensions consist of dispersed solid drug ...

the aim of this study is to formulate a novel ophthalmic nanosuspension (ons), an alternative carrier system to traditional colloidal carriers for controlled release (cr) of acyclovir (acv). in the present study, ons is employed to avoid some of major disadvantages of colloidal carriers systems such as instability in cul de sac and short half life by increasing efficiency of drug encapsulation ...

We have prepared and characterized a new polyurethane-based antimicrobial material, N,N-dodecyl,methyl-polyurethane (Quat-12-PU). It exhibits strong antiviral and antibacterial activities when coated (as an organic solution or an aqueous nanosuspension) onto surfaces and antibacterial activity when electrospun into nanofibers. Quat-12-PU surfaces are able to kill airborne Gram-positive Staphylo...

The present work is aimed at the optimization of nanosuspension of felodipine, a poorly water soluble antihypertensive drug using Full factorial Design. A 3 Full factorial design using Design Expert Version 8.0.7.1was employed to study the effect of the independent variables (diffusing drug concentration and stabilizer concentration) on the dependent variables (particle size, percentage of drug...

Dry eye is both a common symptom and disease. It known that the ophthalmic emulsion of immunomodulator cyclosporine-A (Cyc-A) has positive effect on this condition but its’ absorption to intraocular tissues limited. Nanosuspension drug formulation aims increase bioavailability. The aim study was develop Cyc-A nanosuspension for better via ocular delivery investigate effectiveness by comparing i...

Berberine (Ber), an isoquinoline derivative alkaloid and active ingredient of Coptis, has been demonstrated to possess antidiabetic activities. However its low oral bioavailability restricts its clinical application. In this report, Ber nanosuspension (Ber-NS) composed of Ber and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared by high pressure homogenization technique. Ant...