A naphthalimide-azide based colorimetric and ratiometric fluorescent probe, NAP-1, has been developed for the selective and sensitive detection of hydrogen sulphide. Advantages of the probe NAP-1 include a low detection limit (110 nM), good selectivity, high sensitivity and excellent photostability. A linear relationship between the emission intensity ratios and sulphide concentrations was obse...

A new metal-containing scaffold for the design of protein kinase inhibitors is introduced. Key feature is a 3-(2-pyridyl)-1,8-naphthalimide "pharmacophore chelate ligand" which is designed to form two hydrogen bonds with the hinge region of the ATP-binding site and is at the same time capable of serving as a stable bidentate ligand through C-H-activation at the 4-position of the electron-defici...

A pair of donor-bridge-acceptor electron-transfer complexes, with a carbazole donor and a naphthalimide acceptor connected by either a para- or meta-conjugated phenylacetylene bridge, are synthesized and studied using time-resolved and steady-state spectroscopy. These experiments show that the charge separation times, which depend on the coupling of the donor and acceptor through the excited br...

We report here a mitochondria-targetable pH-sensitive probe that allows for a quantitative measurement of mitochondrial pH changes, as well as the real-time monitoring of pH-related physiological effects in live cells. This system consists of a piperazine-linked naphthalimide as a fluorescence off-on signaling unit, a cationic triphenylphosphonium group for mitochondrial targeting, and a reacti...

Three different kinds of cyclic imides with imido protons are chosen to interact with Hg(II): succinimide, the simplest cyclic imide (five-membered ring); phthalimide (conjugated five-membered ring); and 1,8-naphthalimide (conjugated six-membered ring). Based on the results of MS, (1)H-NMR, XPS, IR spectroscopy and fluorescence response analyses, it is suggested that N-unsubstituted cyclic imid...

In this article, we summarize the synthetic approaches developed in our research groups during last decade to efficiently tune optical, electrochemical and morphological characteristics of oligothiophene–naphthalimide assemblies. Different variables were tuned these organic semiconductors, such as planarity length their ?-conjugated backbones, topology energy levels frontier molecular orbitals ...

Three fluorescent probes TP1–3 for thiols were rationally designed and synthesized to distinguish cysteine (Cys) from glutathione (GSH)/homocysteine (Hcy). TP1–3 are almost non-fluorescent and colorless 4-nitro-1,8-naphthalimide derivatives. Upon the substitution of nitro by Cys, TP1–3 were transformed into weakly fluorescent green-emitting 4-amino analogs via highly fluorescent blue-emitting t...