In this study, twelve neuraminidase (NA) inhibitory compounds 1-12 were isolated from heartwood of Caesalpinia sappan on the basis of their biological activities against three types of viral NAs. Of isolated homoisoflavonoids, sappanone A (2) showed the most potent NAs inhibitory activities with IC(50) values of 0.7 µM [H1N1], 1.1 µM [H3N2], and 1.0 µM [H9N2], respectively, whereas saturated ho...

A 2010 Government Accountability Office (GAO) study reported nearly 40 percent of all delays occurring in the National Airspace System (NAS) were caused by New York airports. In this paper, however, a local network analysis of the NAS elucidates New York’s delay phenomena as multifaceted. Furthermore, a graph theory measure, node strength, is used to analyze directed weighted graphs representin...

THE HEALTH COMMUNITY has been concerned about the health effects of smoking on smokers for over two decades. With recent reports by the Surgeon General' and the National Academy of Sciences,2 a consensus has emerged that smoking also endangers nonsmokers who breathe secondhand smoke (table 1). Although there are always more details to learn, these reports effectively close the scientific case a...

This document describes Diameter applications that are used for Authentication, Authorization and Accounting (AAA) in the Network Access Server (NAS) environment. This application, combined with the Diameter base protocol, Transport Profile, EAP and CMS Security specifications, satisfies typical network access services requirements. Initial deployments of the Diameter protocol are expected to i...

This document describes the research plans of the MRJ Semiconductor Device Modeling Program at NAS as of September 1997. The general motivation and approach for this work is presented first. Then, for each specific project in the program, the motivation, approach, and specific plans for the contract year are described.

In what may be his best book to date, Victor Stenger (Professor Emeritus of Physics) provides a much needed summary, elaboration, and defense of the main theses of the so-called “New Atheists” (NAs), known for their widely-publicized, unrelenting, and passionate critiques of theism and religion in general. Among these NAs, Stenger includes authors of recent bestsellers in the United States: Sam...

This is a descriptive study, aiming at comparing the nursing workload in a post-operatory heart surgery unit (UPOCC) using NAS, TISS-28 and NEMS, and verifying both the observed and recommended nursing staff-to-patient ratio according to the workload indexes used. Data collection happened in a University Hospital, from October to November, 2004. The sample included 55 patients, resulting in 283...

Background: Blunt injuries to the gallbladder occur rarely, and the incidence of isolated damage to the gallbladder is even smaller. We report a case of delayed presentation of isolated rupture of the gallbladder following blunt trauma to the abdomen. Case presentation: A 65 year old lady presented through the Emergency Department with a 1 week history of blunt trauma to her abdomen. She compla...

This paper examines the applications most commonly run on the supercomputers at the Numerical Aerospace Simulation (NAS) facility. It analyzes the extent to which such applications are fundamentally oriented to vector computers, and whether or not they can be e ciently implemented on hierarchical memory machines, such as systems with cache memories and highly parallel, distributed memory system...

Avian influenza A viruses (IAVs) and human 1918, 1957, and 1968 pandemic IAVs all have neuraminidases (NAs) that are stable at low pH sialidase activity, yet most human epidemic IAVs do not. We examined the pH stability of H5N1 highly pathogenic avian IAV (HPAI) NAs and identified amino acids responsible for conferring stability at low pH. We found that, unlike other avian viruses, most H5N1 IA...