Toxoplasma gondii is a ubiquitous protozoan intracellular parasite, the causative agent of toxoplasmosis, and a worldwide zoonosis for which an effective vaccine is needed. Actin is a highly conserved microfilament protein that plays an important role in the invasion of host cells by T. gondii. This study investigated the immune responses elicited by BALB/c mice after nasal immunisation with a ...

BACKGROUND/OBJECTIVE We evaluated the sensitivity of PCR on oral fluids in detecting influenza virus in vaccinated and non-vaccinated pigs. METHODS Three-week-old influenza-free pigs were divided into three groups: (i) control, non-vaccinated, (ii) vaccinated with a commercial, heterologous vaccine, and (iii) vaccinated with an experimental, homologous vaccine. After vaccination, an influenza...

Current influenza vaccines induce strain-specific immunity to the highly variable hemagglutinin (HA) protein. It is therefore a high priority to develop vaccines that induce broadly cross-protective immunity to different strains of influenza. Since influenza A M2 proteins are highly conserved among different strains, five tandem repeats of the extracellular peptide of M2 in a membrane-anchored ...

the main issues in nasal surgery are to stabilize the nose in the good position after surgery and preserve the cartilages and bones in the favorable situation and reduce the risk of deviation recurrence. also it is necessary to avoid the synechia formation, nasal valve narrowing, hematoma and bleeding. due to the above mentioned problems and in order to solve and minimize them nasal packing, na...

A new recombination system for the production of live attenuated influenza-A vaccine strains is described. The attenuated parent is the Japanese strain A/Okuda/ 57 (H2N2) which has a known passage history and a good record of human safety. This virus has been recombined with two recent field isolates, A/England/ 42/72 and A/Finland/4/74, and in each case several recombinants were isolated and t...

introduction rhinoliths are uncommon nasal masses. they are mineralized masses found within the nasal cavity. they have various clinical presentations. case presentation we report a 13-year-old boy with long-standing nasal obstruction, yellowish nasal discharge and intermittent and minimal nasal bleeding for a few weeks, who had been treated as rhinosinusitis twice. due to the presence of long-...

in crooked noses, the lateral walls are different in shape and symmetry. although the septum is very important to obtain a straight nose, identical and symmetrical lateral walls are needed for a straight looking nasal dorsum. as well as the septum, lateral walls also contribute in nasal skeletal support and stability. thus, obtaining identical and symmetrical lateral walls is important. in orde...

Next-generation vaccines for tuberculosis should be designed to prevent the infection and to achieve sterile eradication of Mycobacterium tuberculosis. Mucosal vaccination is a needle-free vaccine strategy that provides protective immunity against pathogenic bacteria and viruses in both mucosal and systemic compartments, being a promising alternative to current tuberculosis vaccines. Micro and ...

BACKGROUND The efficacy of a single dose of an inactivated bovine respiratory syncytial virus (BRSV)--Parainfluenaza type 3 (PI3)--Mannheimia haemolytica (Mh) combination vaccine, in calves positive for maternal antibodies, was established in a BRSV infection study. RESULTS As expected the single vaccination did not have any effect on the decline of BRSV-specific neutralising or ELISA antibod...