The H5N1 influenza A viruses have circulated widely in the avian population for 10 years with only sporadic infection of humans observed and no sustained human to human transmission. Vaccination against potential pandemic strains is one strategy in planning for future influenza pandemics; however, the success of live attenuated vaccines for H5N1 has been limited, due to poor replication in the ...

Zoonotic transmission of brucellosis often results from exposure to Brucella-infected livestock, feral animals, or wildlife or frequently via consumption of unpasteurized milk products or raw meat. Since natural infection of humans often occurs by the oral route, mucosal vaccination may offer a means to confer protection for both mucosal and systemic tissues. Significant efforts have focused on...

Local immunity seems to play a major role in the resistance to infection by rhinoviruses (10). Since foot-and-mouth disease virus (FMDV) shows many of the features of a rhinovirus (8), local immunity in cattle could provide resistance against the disease (7), and it would be possible to appraise it by searching for neutralizing antibodies in nasal secretions. The present work is an investigatio...

BACKGROUND One dose of pandemic influenza vaccine Pandemrix (GlaxoSmithKline) was offered to the entire population of Finland in 2009-10. We conducted a prospective clinical cohort study to determine the vaccine effectiveness in preventing febrile laboratory-confirmed influenza infection during the influenza season 2009-10 and continued the study in 2010-11. METHODS In total, 3,518 community ...

N-trimethyl chitosan (TMC) nanoparticles have been shown to increase the immunogenicity of subunit antigens after nasal and intradermal administration. This work describes a second generation of TMC nanoparticles containing ovalbumin as a model antigen (TMC/OVA nanoparticles) and an immunopotentiator (TMC/OVA/immunopotentiator nanoparticles). The selection of immunopotentiators included Toll-li...

Introduction The relevance of allergic rhinitis is unquestionable. This condition affects people's quality of life and its incidence has increased over the last years. Objective Thus, this study aims to analyze the effectiveness of subcutaneous injectable immunotherapy in cases of nasal itching, sneeze, rhinorrhea and nasal congestion in allergic rhinitis patients. Methods In the present study,...

BACKGROUND Live attenuated influenza vaccines (LAIV) against a variety of strains of pandemic potential are being developed and tested. We describe the results of an open-label phase I trial of a live attenuated H2N2 virus vaccine. OBJECTIVES To evaluate the safety, infectivity, and immunogenicity of a live attenuated H2N2 influenza virus vaccine. PARTICIPANTS/METHODS The A/Ann Arbor/6/60 (...

NEW DRUGS H1N1 Influenza Virus Vaccines The FDA has approved four vaccines to protect the population against the 2009 pandemic H1N1 influenza virus. About 45 million doses should be available at 90,000 sites in October. The government has ordered 195 million doses. CSL Ltd., MedImmune LLC, Sanofi-Pasteur, and Novartis Vaccines/Diagnostics Ltd. are using the same processes to make the H1N1 vacci...

Local immunity seems to play a major role in the resistance to infection by rhinoviruses (10). Since foot-and-mouth disease virus (FMDV) shows many of the features of a rhinovirus (8), local immunity in cattle could provide resistance against the disease (7), and it would be possible to appraise it by searching for neutralizing antibodies in nasal secretions. The present work is an investigatio...

Allergic rhinitis (AR) is a common, frequently occurring disease with increasing incidences every year. House dust mite is one of the common indoor allergens that causes allergic rhinitis. So this study was aimed to evaluate the efficacy and safety of Allergopharma house dust mite vaccine in the treatment of allergic rhinitis. A case self-control method was used to compare the total symptom usi...