The renin-angiotensin system (RAS) is a principal determinant of arterial blood pressure and fluid and electrolyte balance. RAS component dysregulation was recently found in some malignancies and correlated with poor patient outcomes. However, the exact mechanism of local RAS activation in tumors is still unclear. Here, we find that the local angiotensin II predominantly exists in the hypoxic r...

Platinum-based concurrent chemoradiotherapy is considered a standard treatment approach for locoregionally advanced nasopharyngeal carcinoma. However, only a minority of patients benefit from this treatment regimen compared with radiotherapy alone. Identification of a set of molecular markers predicting sensitivity of platinum-based chemotherapy may contribute to personalized treatment of patie...

OBJECTIVES To increase awareness of the potential coexistence of connective tissue disease and nasopharyngeal carcinoma in a Western population, to consider possible causes for this phenomenon, and to provide recommendations for clinical management. DESIGN Case report. SETTING Academic tertiary referral practice. PATIENTS Ninety-four patients with nasopharyngeal carcinoma were initially t...

BACKGROUND AND OBJECTIVE In nasopharyngeal cancer, conventional white light endoscopy does not provide adequate information to detect the flat/small lesion and identify the margin of observable tumor. In the present study, we evaluate the potential of light-induced fluorescence spectroscopic imaging for the localization of cancerous nasopharyngeal tissue. STUDY DESIGN/MATERIALS AND METHODS We...

RATIONALE Nasopharyngeal amyloidosis is a benign, slowly progressive disease that is characterized by extracellular eosinophilic deposition. PATIENT CONCERNS We report a rare case of localized nasopharyngeal amyloidosis. DIAGNOSES The initial chief complaint of this patient was frequent epistaxis and right aural fullness. The initial diagnosis was nasopharyngeal tumor. INTERVENTIONS There...

Introduction Radiotherapy is regarded as the first treatment of choice for nasopharyngeal carcinoma. Despite the advantages of radiotherapy, patients may suffer from a wide range of side-effects due to the presence of many sensitive normal tissues in these regions. If the absorbed dose exceeds the tolerance level in parotid glands and the spinal cord, myelopathy, Lhermitte's sign and xerostomia...

BACKGROUND AND PURPOSE Although the role of gray-scale sonography for neck nodes is well documented, it plays a limited role in the evaluation of nodal response to treatment. This preliminary limited study sought to determine color duplex sonographic changes in successfully treated metastatic nodes from nasopharyngeal carcinoma. METHODS Fourteen patients with nodal metastases from nasopharyng...

We performed a logistic regression analysis to evaluate the predictive value of ultrasonongraphy-detectable features of cervical lymph nodes in patients with nasopharyngeal carcinoma. The goal of this analysis was to determine whether certain ultrasound features were useful for accurate differential diagnosis of cervical lymph nodes metastasis with underlying nasopharyngeal carcinoma. In this i...

BACKGROUND Previous work has proposed that celecoxib may be able to enhance the effects of radiotherapy. However, the underlying mechanism of this activity has not yet been determined. METHODS The cell colony formation assay after the combination of celecoxib and radiation treatment was done on C666-1, CNE-1 and CNE-2 nasopharyngeal carcinoma cells, which expressed different COX-2 levels. Mor...

Choanal stenosis is a well recognized late complication of radiotherapy for nasopharyngeal carcinoma. However velopharyngeal stenosis post radiotherapy for nasopharyngeal carcinoma is rare. We present here a case of bilateral choanal stenosis and velopharyngeal stenosis in a patient treated with radiotherapy for nasopharyngeal carcinoma. A 58-year-old woman presented to our otolaryngology clini...