Radioprotecting ability of the natural polyphenol, gallic acid (3,4,5-trihydroxybenzoic acid, GA), was investigated in Swiss albino mice. Oral administration of GA (100 mg/kg body weight), one hour prior to whole body gamma radiation exposure (2-8 Gy; 6 animals/group), reduced the radiation-induced cellular DNA damage in mouse peripheral blood leukocytes, bone marrow cells, and spleenocytes as ...

In experiments on mice the study of radioprotective and radiotherapeutic efficacy combined use selenium-containing feed additive DAFS-25k iodine-containing preparation Monclavit-1 was carried out. It has been shown that intragastric administration oil solution 3 hours before total, external, single exposure to γ-radiation, subsequent (in 12 hours) an aqueous Monclavit-1, increases survival rate...

Human beings are at risk of the exposure of radiation or radioactive materials since the World War II. Nuclear proliferation and terrorist activities has further strengthened the threats of the exposure of ionizing radiation (IR) to military, civilian, and emergency responders. IR possesses sufficient energy to strip electrons from atoms or molecules and thereby create highly reactive ions. IR ...

Guduchi is a plant also known as Tinospora cordifolia, having heart shaped leave, an herb of the family Menispermaceae native hot areas Indian subcontinent. In our classical Ayurvedic texts, it indicated to be beneficial in treating various types diseases like skin disorders, different fever, jaundice & gout. claimed have properties anti-oxidant, antihyperglycemic, antihyperlipidemic, hepat...

Both protection and sensitization of Mice C57Bl against 60Co gamma-rays by sulfur-containing amino acid derivatives--S-alkyl-L-cysteines, S-alkyl-2-methyl-DL-cysteines and their hydantoin derivatives, and sulfoxides of these compounds--were examined. DL-5 Allylthiomethyl-5-methylhydantoin (150 mg/kg body weight) had a remarkable radioprotective effect. The survival ratio was 4.3 or above two ti...

Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather ...

Pyrroloquinoline quinone (PQQ) was produced by fermentation of the Methylovorus sp. MP688 strain and purified by ion-exchange chromatography, crystallization and recrystallization. The yield of PQQ reached approximately 125 mg/L and highly pure PQQ was obtained. To determine the optimum dose of PQQ for radioprotection, three doses (2 mg/kg, 4 mg/kg, 8 mg/kg) of PQQ were orally administrated to ...