Twenty two patients with gender dysphoria underwent neo-phalloplasties using a novel technique. Latissimus dorsi musculocutaneus re-innervated free flap was used to allow voluntary rigidity of the neo-penis. From the first 22 patients, 18 have obtained motoric function of reconstructed penis; the "paradox erection" was obtained. 14 patients came for examination after a follow-up period of mean ...

Emerging evidences suggest the heterogeneity of cancers limits the efficacy of immunotherapy. To search for optimal therapeutic targets, we used whole-exome sequencing data from 23 early cervical tumors from Chinese women to investigate the hierarchical structure of the somatic mutations and the predicted neo-epitopes based on their strong binding with major histocompatibility complex class I m...

The recent efforts to identify and analyse the neo-Kantian roots of logical positivism have primarily concentrated on the impact of the Marburg School on Carnap and Schlick. Among the Marburgers, attention focused primarily on Ernst Cassirer. From among the contemporaries of the neo-positivists he is commonly regarded as their leading representative. In view of the different currents of the man...

sahand volcanic-sub-volcanic dome, along with several other magmatic domes in northwest iran and the southern part of tabriz fault show adakitic geochemical characteristics. sahand dome has mainly dacitic composition. the sio2 content and mg number of sahand dome range from 64 to 73 wt% and 27 to 57 respectively. sahand dome can be classified as high silica adakitic (hsa) type. the rocks studie...

OBJECTIVE Regarding neo-aortic valve regurgitation (neo-AR) after the arterial switch operation (ASO), the 'trap-door' technique was supposed to be a risk factor due to a distortion of the sinotubular junction (STJ) geometry. Here we report our results of the 'trap-door' technique with a special emphasis on root geometry including the ratio of STJ to annulus. METHODS From August 1991 to March...

The orbital and absolute magnitude distribution of the near-Earth objects (NEOs) is difficult to compute, partly because only a modest fraction of the entire NEO population has been discovered so far, but also because the known NEOs are biased by complicated observational selection effects. To circumvent these problems, we created a model NEO population which was fit to known NEOs discovered or...

The amygdala has emerged as an important forebrain modulator of arousal. Acetylcholine plays a role in the regulation of sleep and wakefulness, particularly rapid eye movement sleep (REM). The major cholinergic input to the amygdala comes from the basal forebrain, a region primarily linked to wakefulness. We examined sleep and the encephalogram for 8 h following bilateral microinjections into t...

Mouse cone photoreceptors, like those of most mammals including humans, express cone opsins derived from two ancient families: S-opsin (gene Opn1sw) and M-opsin (gene Opn1mw). Most C57Bl/6 mouse cones co-express both opsins, but in dorso-ventral counter-gradients, with M-opsin dominant in the dorsal retina and S-opsin in the ventral retina, and S-opsin 4-fold greater overall. We created a mouse...

Planning systems such as FF-Metric [3] and SAPA [2] are able to deal with numerical knowledge to solve resources constraints added to the symbolic planning domain. This paper presents the NGP (Numerical Graph Planning) that is able to solve totally numerical and/or symbolic planning domains. We propose a new action representation to support numerical conditions and effects, where we allow a non...