Blood culture, the gold standard for diagnosis of neonatal sepsis has low sensitivity and is time consuming. Therefore, objective is development and application of Polymerase chain reaction (PCR)-based DNA sequencing to detect and identify bacterium causing neonatal sepsis in culture negative specimens. Sixty three peripheral blood and 8 cerebrospinal fluid (CSF) referred from tertiary level Ne...

OBJECTIVE To determine the validity of C-reactive protein levels for diagnosis of neonatal sepsis. METHODS A cross sectional (Validation) study was conducted at Neonatology unit in KRL general hospital (emergency/OPD) of 7 months duration from February 2012 to August 2012. By using purposive sampling technique, 147, sample size was calculated by using WHO sample size calculator taking sensiti...

BACKGROUND Early onset sepsis remains a major cause for neonatal morbidity and mortality. OBJECTIVES The aim of this study was to describe and compare the clinical and laboratory characteristics of neonates in neonatal intensive care unit with culture positive and negative early onset sepsis and verify if there were any differences between the groups. METHODS A one year comparative prospect...

Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with produc...

  Objective(s): Bacterial infection contributes substantially to neonatal morbidity and mortality. Early diagnosis of neonatal sepsis is difficult because clinical signs are non-specific. We have evaluated serum IL-6, 8 and 10 as potential early diagnostic markers of neonatal infection and their relationship to mortality rate and poor prognosis.   Materials and Methods : A total ...

Neonatal sepsis is a significant health issue associated with high mortality. Immune responses associated with neonatal sepsis, such as proinflammatory cytokine production, are believed to play a central role in the pathogenesis of this disease. In the present study, serum levels of the proinflammatory cytokines TNF-α, IL1-β, and IL-6 and the anti-inflammatory cytokines IL-4 and IL-10 were eval...

Infection in neonates, particular the neonatal sepsis continues to be a global problem with significant morbidity and mortality. The diagnosis of neonatal sepsis is complicated by nonspecific clinical symptomatology, a high-false negative rate, and a delay in obtaining blood culture results. MicroRNAs (miRNAs) have recently been used as finger prints for sepsis, and have been validated to be po...

Background Neonatal sepsis is a critical condition caused by a generalized bacterial infection in the first month of life. The present study aimed to investigate the relationship between serum vitamin D levels and neonatal sepsis. Materials and Methods: A search of online databases (Medl...

Neonatal sepsis is a common cause of neonatal morbidity and mortality in developing countries. It is a serious bacterial infection of blood with a clinical syndrome characterized by systemic signs of infection and bacteremia in the first month of life. Factors associated with positive blood culture and perinatal deaths among neonates are rarely described in developing countries. This study aime...

BACKGROUND It has recently been suggested that serum procalcitonin (PCT) is of value in the diagnosis of neonatal sepsis, with varying results. The aim of this prospective multicenter study was to assess the usefulness of PCT as a marker of neonatal sepsis of nosocomial origin. METHODS One hundred infants aged between 4 and 28 days of life admitted to the Neonatology Services of 13 acute-care...