Protein toxins are important virulence factors contributing to neonatal sepsis. The major pathogens of neonatal sepsis, group B Streptococci, Escherichia coli, Listeria monocytogenes, and Staphylococcus aureus, secrete toxins of different molecular nature, which are key for defining the disease. Amongst these toxins are pore-forming exotoxins that are expressed as soluble monomers prior to enga...

Interleukin (IL)-18 is an important effector of innate and adaptive immunity, but its expression must also be tightly regulated because it can potentiate lethal systemic inflammation and death. Healthy and septic human neonates demonstrate elevated serum concentrations of IL-18 compared with adults. Thus, we determined the contribution of IL-18 to lethality and its mechanism in a murine model o...

A prospective observational study was conducted in a neonatal unit of referral teaching hospital North India with an aim to the bacteriological profile and sensitivity pattern referred neonates. During this period one year, incidence culture positive sepsis 34 % among which gram-negative bacilli predominated both early onset late sepsis. In sepsis, predominant organism Klebsiella pneumoniae fol...

OBJECTIVES We determined whether initial antithrombin (AT) levels help in diagnosis and prognosis of neonatal sepsis. METHODS Sepsis was diagnosed according to clinical and laboratory findings and positive culture results in 34 of the 54 newborns who presented to the hospital with suspected sepsis. Between AT levels and hematological parameters (fibrinogen levels, prothrombin time (PT), activ...

Objective: To analyse the Gram-negative bacteriological profile of nosocomial sepsis and antibiotic susceptibility patterns. Methods: Neonates clinically diagnosed with sepsis and whose blood cultures tested positive for Gram-negative microorganisms from 2002 to 2008, retrospectively. Results: 143 cases of neonatal sepsis caused by Gram-negative microorganisms were identified. Eighty-one percen...

This study aimed to investigate the etiology and risk factors of neonatal sepsis. A retrospective analysis was conducted on 192 patients with sepsis from August 2013 to March 2015. One hundred and six healthy neonates were used as the control group. Logistic regression was used to analyze the risk factors and ROC curve analysis performed in laboratory which indicated a significant correlation. ...

Background: Neonatal sepsis is one of the common causes neonatal mortality. Blood culture gold standard procedure to confirm sepsis. However, rapid rate disease progression makes its timely diagnosis and prompt management very crucial before availability culture. The study aimed determine significance complete blood count parameters including platelet indices in diagnosing Materials Methods: Th...

The broad-spectrum activity of fosfomycin, including against multidrug-resistant (MDR) strains, has led to renewed interest in its use in recent years. Neonatal sepsis remains a substantial cause of morbidity and mortality at a global level, with evidence that MDR bacteria play an increasing role. The evidence for use of fosfomycin in neonatal subjects is limited. We summarise current knowledge...

Background: Microorganisms that cause early neonatal sepsis are usually already colonized rectovaginal area in mothers. The most common of these organisms is group B streptococci (GBS) and intestinal gram-negative bacteria mostly Escherichia coli (E.coli). The use of prophylactic antibiotics against GBS has increased in recent years. This study aimed to determine the current situation and frequ...

Objectives: Infections in infants<90 days old are the leading cause of morbidity and hospitalization in neonatal practice. The etiological agents of sepsis (with or without meningitis) in Saudi neonates <90 days old are vastly undercharacterized. The aim of this study was to determine the bacterial etiology of neonatal sepsis and meningitis in these infants. Materials and methods: This retrospe...