Globally, an estimated 500,000 newborns die each year from serious neonatal infections, which account for about 15% of all neonatal deaths. “Suspected sepsis” is one of the most common reasons for admission to the neonatal intensive care unit (NICU). The challenge to the physician has always been trying to differentiate newborns with early onset sepsis from other non-infectious pathology whose ...

background: microorganisms that cause early neonatal sepsis are usually already colonized rectovaginal area in mothers. the most common of these organisms is group b streptococci (gbs) and intestinal gram-negative bacteria mostly escherichia coli (e.coli). the use of prophylactic antibiotics against gbs has increased in recent years. this study aimed to determine the current situation and frequ...

conclusions sepsis enhances the production of plasma ngal in critically ill neonates. thus plasma ngal can help clinicians diagnose sepsis in critically ill neonates during early phases. results the ngal levels were significantly higher in septic neonates compared with non-septic neonates (102.9 ± 69.9 ng/ml versus 29.2 ± 13.3 ng/ml, p value = 0.0001). an optimal cut off-point of 48 ng/ml for s...

Background: Thrombocytopenia (TTP) is one of the most common neonatal hematological disorders. The causes of neonatal TTP are very various, leading to large differences in the clinical profile of the affected neonates. Therefore, the aim of this study was to investigate the characteristics, clinical diagnoses and short-term outcomes of neonatal TTP in Bahrami Children's Hospital. Material and ...

Neonatal sepsis is a significant cause of morbidity and mortality among neonates worldwide. World Health Organization has estimated that 1.6 million deaths occur globally every year due to neonatal infections and 40% of all neonatal deaths occur in developing countries (WHO report 2006). In India, the incidence of blood culture proven sepsis was reported as 8.5 per 1,000 live births for the yea...

BACKGROUND Neonatal sepsis is a worldwide public health issue in which, depending on the studied population, marked variations concerning its risk and prognostic factors have been reported. The aim of this study was to assess risk and prognostic factors for neonatal sepsis prevailing at a medical unit in southeastern Mexico. Thus, we used a historic cohort design to assess the association betwe...

A meta-analysis was performed to assess the accuracy of the procalcitonin (PCT) test for diagnosing neonatal sepsis. The major databases, MEDLINE, EMBASE and the Cochrane Library were searched for studies published between January 1996 and May 2009 that evaluated PCT as a diagnostic marker for neonatal sepsis and provided sufficient data to calculate sensitivity and specificity. Twenty-two stud...

Neonatal sepsis is a life-threatening disease. Early diagnosis essential, but no single marker of infection has been identified. Sepsis activates coagulation cascade with simultaneous production the D-dimers due to lysis fibrin. D-dimer test reflects activation system.

QUALITY PROBLEM OR ISSUE Incorrect and excessive diagnosis of newborn infections in Nicaragua caused overcrowding in the neonatal intensive care units and unnecessary hospitalization. INITIAL ASSESSMENT A baseline study in nine hospitals found that none correctly utilized disinfectants, sterilization or hand hygiene and that diagnosis of neonatal sepsis was based primarily on clinical manifes...

OBJECTIVE To review the incidence of neonatal group B streptococcal (GBS) sepsis and its associated risk factors in our obstetrical population. METHODS A computerized perinatal database of over 17,000 births (from 1992 to 1996) was queried for the incidence of neonatal GBS sepsis. A more detailed review of 895 births (from the first quarter of 1997) was undertaken to identify the incidence of...