Tinospora crispa Beumee, a herbaceous climber, has been widely used in traditional medicine for treating various ailments such as contusion, septicaemia, fever, fracture, scabies and other tropical ulcers. A wide range of secondary metabolites such as alkaloids, diterpenes, flavones, phenolics, and triterpenes have been isolated, some of which have also shown corresponding biological activities...

We investigated the in vivo antimalarial effect of crude extract of Tinospora crispa, a Thai traditional medicine plant. Mice were inoculated with Plasmodium yoelii then treated with the crude extract of Tinospora crispa at doses of 20, 40 and 80 mg/kg. Mice receiving the dose of 20 mg/kg died on average on Day 8. Mice remained alive longer when treated of the dose of 40 mg/kg or even longer un...

The high prevalence of pediculosis capitis, commonly known as head lice (Pediculus humanus capitis) infestation, has led to the preparation of a community-based pediculicidal ointment, which is made of common household items and the extract of Tinospora crispa stem. The present study aimed to evaluate the safety, efficacy, and physicochemical characteristics of the T. crispa pediculicidal ointm...

The antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine and rich in antioxidant, were explored based on obesity-linked insulin resistance condition. Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which received standard rodent diet, the high fat diet (HFD) which received high fat diet only, the high...

Iranian Traditional Medicine (ITM) describes a kind of dementia with similar signs and symptoms of Alzheimer's disease (AD). It explains the pathology of dementia with cold intemperament of the brain, which means that the brain is colder than its healthy form. ITM strategy for treatment of dementia is to heat the brain up by medical "hot" herbs. Nepeta menthoides (NM) is one of these "hot" herb...

Objective To establish the method for quantitative determination of oleanolic acid in Hedyotis diffusa Willd., and study its inhibitory effect on human hepatoma HepG-2 cells. Methods HPLC with a column of Angilent ZORBAX Eclips Plus C18 (4.6 × 250 mm, 5 um) is used; column temperature: 20°C. Detection wavelength: 210nm. Anti-hepatoma activity of Hedyotis diffusa Willd. is analyzed by observing ...

Medicinal plants play an important role in the treatment of a wide range of diseases, even if their chemical constituents are not always completely recognized. Observations on their use and efficacy significantly contribute to the disclosure of their therapeutic properties. Calamintha nepeta (L.) Savi is an aromatic herb with a mint-oregano flavor, used in the Mediterranean areas as a tradition...

Result: In total, 43 components were identified in Hedyotis diffusa Willd. The identified components comprised 11 alcohols, 7 alkenes, 5 ketones, 7 aldehydes, 6 acid substances, 2 esters, 5 other substances. The major components in the Hedyotis diffusa WILLD oil were Hexadecanoic acid (48.89%) followed by Pentadecanoic acid (6.11%), D-Limonene (5.74%) and fatty acid were the most abundant compo...

Hedyotis Diffusa Willd has been used as a major component in several Chinese medicine formulations for the clinical treatment of colorectal cancer. However, the molecular mechanism of the anti-cancer activity of Hedyotis Diffusa Willd remains unclear. In the present study, we investigated the cellular effects of the ethanol extract of Hedyotis Diffusa Willd (EEHDW) in the HT-29 human colon carc...